The role of MHC class I and class II molecules in susceptibility to Lyme disease in inbred B10 H-2 congenic and recombinant mice

Sunitha Reddy; Colin R. Young; Regina Hokanson; Julie Rawlings; Chella S. David

doi:10.1007/BF02043624

International Journal of Angiology, Table of Contents

Int J Angiol 1995; 4(2): 88-93
DOI: 10.1007/BF02043624

Original Articles

The role of MHC class I and class II molecules in susceptibility to Lyme disease in inbred B10 H-2 congenic and recombinant mice

Sunitha Reddy¹ , Colin R. Young² , Regina Hokanson² , Julie Rawlings³ , Chella S. David⁴

¹Department of Biology, Texas A&M University, College Station, Texas
²Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas
³Texas Department of Health, Austin, Texas
⁴Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA

Presented at the 35th Annual World Congress, International College of Angiology, Copenhagen, Denmark, July 1993

Abstract

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Abstract

We have further developed the mouse model of Lyme disease using B10 H-2 congenic and recombinant strains. The influence of MHC class I and class II genes of the mouse H-2 complex on the susceptibility and/or resistance to Lyme disease was studied. We report that B10 strains congenic to the haplotypes, H-2^k, H-2^d, H-2^f, H-2^q, and H-2^b are highly susceptible to Lyme disease as they develop high antibody titers and severe disease over mice of other haplotypes used in this study. By using recombinant strains we demonstrate that this susceptibility is genetically based and specifically involves the K and D regions (MHC class I genes) and I-A and I-E regions (MHC class II genes) of the H-2 complex.

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