Dtsch Med Wochenschr 2019; 144(16): 1138-1144
DOI: 10.1055/a-0835-7851
Review
© Georg Thieme Verlag KG Stuttgart · New York

Beurteilung und akutes Management der dekompensierten Klappenvitien auf der Intensivstation – eine aktuelle Übersicht

Assessment and Acute Management of Decompensated Heart Valves in the Intensive Care Unit – a Current Review
Sebastian Reith
1   Medizinische Klinik III, St.-FranziskusHospital Münster
,
Andreas Napp
2   Medizinische Klinik I, Universitätsklinikum der RWTH Aachen
› Author Affiliations
Further Information

Publication History

Publication Date:
15 August 2019 (online)

Zusammenfassung

Die akute valvuläre Dysfunktion ist eine zunehmend häufigere und kritische Ursache einer intensivmedizinischen Behandlung einer dekompensierten Herzinsuffizienz mit dem Auftreten eines kardiogenen Schocks als der schwerwiegendsten Form. Während es definierte Leitlinien sowohl für die Diagnostik und Therapie der Herzinsuffizienz als auch für stabile Patienten mit Herzklappenfehlern gibt, ist die Datenlage bei akut valvulär dekompensierten Patienten begrenzt. Bei drohender oder bestehender Organdysfunktion trotz Ausschöpfung aller medikamentösen Therapieoptionen stehen neben den chirurgischen Klappenoperationen verschiedene Katheter-interventionelle Therapieoptionen wie das TAVI- und das MitraClip-Verfahren zur Verfügung. Darüber hinaus haben zuletzt die Ballonvalvuloplastie bei der Aortenklappenstenose sowie perkutane Kreislaufunterstützungssysteme einen wachsenden Stellenwert bei der Behandlung und hämodynamischen Stabilisierung von dekompensierten Klappenpatienten auf der Intensivstation erlangt.

Abstract

The acute valvular dysfunction is a rapidly growing and critical condition in the intensive care unit with a cardiogenic shock as the most serious clinical entity. There are clearly defined guidelines for the diagnosis and treatment of heart failure and for stable patients with valvular heart disease. However, data regarding acutely valvular decompensated patients are currently limited. In case of secondary organ dysfunction despite optimal medical treatment, various percutaneous interventional procedures such as TAVI and MitraClip are now available besides surgical valvular repair. Moreover, balloon valvuloplasty for aortic stenosis and percutaneous mechanical circulatory support devices are emerging tools for the treatment and stabilization of valvular decompensated patients in the intensive care unit.

 
  • Literatur

  • 1 Nieminen MS, Brutsaert D, Dickstein K. et al. Euro Heart Survey Euro Heart Failure Survey II (EHFS II): a survey on hospitalized acute heart failure patients: description of population. Eur Heart J 2006; 27: 2725-2736
  • 2 Baumgartner H, Falk V, Bax JJ. et al. 2017 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J 2017; 38: 2739-2791
  • 3 Ponikowski P, Voors AA, Anker SD. et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 2016; 37: 2129-2200
  • 4 Thiele H. Cardiogenic shock: Current evidence. Herz 2017; 42: 795-806
  • 5 Hoefer D, Jonetzko P, Hoermann C. et al. Successful administration of levosimendan in a patient with low-gradient low-output aortic stenosis. Wien Klin Wochenschr 2006; 118: 60-62
  • 6 Iung B, Baron G, Butchard EG. et al. A prospective survey of patients with valvular heart disease in Europe: the Euro Heart survey on valvular heart disease. Eur Heart J 2003; 24: 1231-1243
  • 7 Bongiovanni D, Kühl C, Bleiziffer S. et al. Emergency treatment of decompensated aortic stenosis. Heart 2018; 104: 23-29
  • 8 Frerker C, Schewel J, Schlüter M. et al. Emergency transcatheter aortic valve replacement in patients with cardiogenic shock due to acutely decompensated aortic stenosis. EuroIntervention 2016; 11: 1530-1536
  • 9 Kodali SK, Williams MR, Smith CR. et al. Two year outcomes after transcatheter or surgical aortic valve replacement. N Engl J Med 2012; 366: 1686-1695
  • 10 Ben-Dor I, Maluenda G, Dvir D. et al. Balloon aortic valvuloplasty for severe aortic stenosis as a bridge to transcatheter/surgical aortic valve replacement. Catheter Cardiovasc Interv 2013; 82: 632-637
  • 11 Moretti C, Chandran S, Vervueren PL. et al. Outcomes of patients undergoing balloon aortic valvuloplasty in the TAVI era: a multicenter registry. J Invasive Cardiol 2015; 27: E2772-E2784
  • 12 Geppert A. Patients in the intensive care unit with valvular disease. Med Klin Intensivmed Notfmed 2013; 108: 555-560
  • 13 Debry N, Kone P, Vincent F. et al. Urgent balloon aortic valvuloplasty in patients with cardiogenic shock related to severe aortic stenosis: time matters. EuroIntervention 2018; 14: e519-e525
  • 14 Kolte D, Khera S, Vemulapallui S. et al. Outcomes following urgent/emergent transcatheter aortic valve replacement: insights from the STS/ACC TVT Registry. JACC Cardiovasc Interv 2018; 11: 1175-1185
  • 15 van Belle E, Juthier F, Susen S. et al. Postprocedural aortic regurgitation in ballon expandable and self-expandable transcatheter aortic valve replacement procedures: analysis of predictors and impact on long-term mortality: insights from the FRANCE2 registry. Circulation 2014; 29: 1415-1427
  • 16 Arnold SV, Reynolds MR, Wang K. et al. Health Status After Transcatheter or Surgical Aortic Valve Replacement in Patients With Severe Aortic Stenosis at Increased Surgical Risk: Results From the CoreValve US Pivotal Trial. JACC Cardiovasc Interv 2015; 8 (09) 1207-1217
  • 17 Walther T, Hamm CW, Schuler G. et al. Perioperative results and complications in 15964 transcatheter aortic valve replacements: prospective data from the GARY registry. J Am Coll Cardiol 2015; 65: 2173-2180
  • 18 Martinez CA, Singh V, Londono JC. et al. Percutaneous retrograde left ventricular assist support for interventions in patients with aortic stenosis and left ventricular dysfunction. Catheter cardiovasc Interv 2012; 80: 1201-1209
  • 19 Singh V, Mendirichaga R, Inglessis-Azuaje I. et al. The role of impella for hemodynamic support with aortic stenosis. Curr Treat Options Cardio Med 2018; 20: 44
  • 20 Singh V, Yadav PK, Eng MH. et al. Outcomes of hemodynamic support with Impella in very high-risk patients undergoing balloon aortic valvuloplasty: results from the Global CVAD registry. Int J Cardiol 2017; 240: 120-125
  • 21 Singh V, Damluji AA, Mendirichaga R. et al. Elective or emergency use of mechanical circulatory support devices during transcatheter aortic valve replacement. J Interv Cardiol 2016; 29: 513-522
  • 22 Ganapathi AM, Hirji SA, Wang A. et al. Bridge to long-term mechanical circulatory support with a left ventricular assist device: novel use of transcatheter aortic valve replacement. Ann Thorac Surg 2015; 99: e91-e93
  • 23 Wada Y, Ohara T, Funada A. et al. Prognostic impact of functional mitral regurgitation in patients admitted with acute decompensated heart failure. Circulation Journal 2016; 80: 139-147
  • 24 Baldus S, Schillinger W, Franzen O. et al. MitraClip therapy in daily clinical practice: initial results from the German transcatheter mitral valve interventions (TRAMI) registry. Eur J Heart Fail 2012; 14: 1050-1055
  • 25 Nickenig G, Estevez-Loureiro R, Franzen O. et al. Percutaneous mitral valve edge-to-edge repair: In-hospital results and 1-year follow-up of 628 patients of the 2011–2012 Pilot European Sentinel Registry. J Am Coll Cardiol 2014; 64: 875-884
  • 26 Stone GW, Lindenfeld J, Abraham WT. et al. Transcatheter Mitral-Valve Repair in Patients with Heart Failure. N Engl J Med 2018; 379: 2307-2318
  • 27 Pleger ST, Chorianopoulos E, Krumsdorf U. et al. Percutaneous edge-to-edge repair of mitral regurgitation as a bail-out strategy in critically ill patients. J Invasive Cardiol 2012; 25: 69-72
  • 28 Jalil B, El-Kersh K, Frizzell J. et al. Impella percutaneous left ventricular assist device for severe acute ischaemic mitral regurgitation as a bridge to surgery. BMJ Case Rep 2017; DOI: 10.1136/bcr-2017-219749.
  • 29 Achkouty G, Amabile N, Zannis K. et al. Transcatheter aortic valve replacement for severe aortic regurgitation with refractory cardiogenic shock. Can J Cardiol 2018; 34: e5-e342
  • 30 Antunes MJ, Rodriguez-Palomares J, Prendergast B. et al. Management of tricuspid valve regurgitation – Position Statement of the European Society of Cardiology Groups of cardiovascular surgery and valvular heart disease. Eur J Cardiothorac Surg 2017; 52: 1022-1030