Placeboeffekte in wissenschaftlichen Studien

Zahlreiche Studien zu Placebo-Operationen bei Knie-, Schulter- oder Rückenschmerzen zeigen, dass diese genauso gut wirken wie „echte“ OPs. Die wissenschaftliche Evidenz belegt auch, dass manche Schmerzmedikamente nicht effektiver sind als Placebo-Analgetika. Und selbst in der Physiotherapie gibt es Placeboeffekte. Diese Effekte sind nicht verwerflich, sondern können gezielt genutzt werden.

Publication History

Article published online:
21 October 2020

• Literatur

• 1 Moseley JB, OʼMalley K, Petersen NJ. et al. A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med 2002; 347 (02) 81-88 doi:10.1056/NEJMoa013259
• 2 Sihvonen R, Paavola M, Malmivaara A. et al. Arthroscopic partial meniscectomy versus sham surgery for a degenerative meniscal tear. N Engl J Med 2013; 369 (26) 2515-2524 doi:10.1056/NEJMoa1305189
• 3 Thorlund JB, Juhl CB, Roos EM. et al. Arthroscopic surgery for degenerative knee: systematic review and meta-analysis of benefits and harms. Br J Sports Med 2015; 49 (19) 1229-1235 doi:10.1136/bmj.h2747
• 4 Siemieniuk RAC, Harris IA. Agoritsas Tet al. Arthroscopic surgery for degenerative knee arthritis and meniscal tears: a clinical practice guideline. BMJ 2017; 357: j1982 doi:10.1136/bmj.j1982
• 5 Beard DJ, Rees JL, Cook JA. et al. Arthroscopic subacromial decompression for subacromial shoulder pain (CSAW): a multicentre, pragmatic, parallel group, placebo-controlled, three-group, randomised surgical trial. Lancet 2018; 391(10118): 329-338 doi:10.1016/S0140-6736(17)32457-1
• 6 Paavola M, Malmivaara A, Taimela S. et al. Subacromial decompression versus diagnostic arthroscopy for shoulder impingement: randomised, placebo surgery controlled clinical trial. BMJ 2018; 362: k2860 doi:10.1136/bmj.k2860
• 7 Vandvik PO, Lähdeoja T, Ardern C. et al. Subacromial decompression surgery for adults with shoulder pain: a clinical practice guideline. BMJ 2019; 364: l294 doi:10.1136/bmj.l294
• 8 Louw A, Diener I, Fernández-de-Las-Peñas C. et al. Sham Surgery in Orthopedics: A Systematic Review of the Literature. Pain Med 2017; 18 (04) 736-750 doi:10.1093/pm/pnw164
• 9 Machado GC, Maher CG, Ferreira PH. et al. Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials. BMJ 2015; 350: h1225 doi:10.1136/bmj.h1225
• 10 Maher CG, Lin C, Mathieson S. et al. Trial of Pregabalin for Acute and Chronic Sciatica. N Engl J Med 2017; 376 (12) 1111-1120 doi:10.1056/NEJMc1705241
• 11 Friedman BW, Irizarry E, Solorzano C. et al. Diazepam Is No Better Than Placebo When Added to Naproxen for Acute Low Back Pain. Ann Emerg Med 2017; 70 (02) 169-176 e1 doi:10.1016/j.annemergmed.2016.10.00
• 12 Machado GC, Maher CG, Ferreira PH. et al. Non-steroidal anti-inflammatory drugs for spinal pain: a systematic review and meta-analysis. Ann Rheum Dis 2017; 76 (07) 1269-1278 doi:10.1136/annrheumdis-2016-210597
• 13 Armagan O, Bakilan F, Ozgen M. et al. Effects of placebo-controlled continuous and pulsed ultrasound treatments on carpal tunnel syndrome: a randomized trial. Clinics (Sao Paulo) 2014; 69 (08) 524-528 doi:10.6061/clinics/2014(08)04
• 14 Khadilkar A, Odebiyi DO, Brosseau L. et al. Transcutaneous electrical nerve stimulation (TENS) versus placebo for chronic low-back pain. Cochrane Database Syst Rev 2008; (04) CD003008 DOI: 10.1002/14651858.CD003008.pub3.
• 15 Chaibi A, Benth JŠ, Tuchin PJ. et al. Chiropractic spinal manipulative therapy for migraine: a three-armed, single-blinded, placebo, randomized controlled trial. Eur J Neurol 2017; 24 (01) 143-153 doi:10.1111/ene.13166
• 16 Moraska AF, Stenerson L, Butryn N. et al. Myofascial trigger point-focused head and neck massage for recurrent tension-type headache: a randomized, placebo-controlled clinical trial. Clin J Pain 2015; 31 (02) 159-168 doi:10.1097/AJP.0000000000000091
• 17 Bennell KL, Hinman R, Metcalf B. et al. Efficacy of physiotherapy management of knee joint osteoarthritis: a randomised, double blind, placebo controlled trial. Ann Rheum Dis 2005; 64 (06) 906-912 doi:10.1136/ard.2004.026526
• 18 Costa L, Maher CG, Latimer J. et al. Motor control exercise for chronic low back pain: a randomized placebo-controlled trial. Phys Ther 2009; 89 (12) 1275-1286 doi:10.2522/ptj.20090218
• 19 Moseley GL, Nicholas MK, Hodges PW. A randomized controlled trial of intensive neurophysiology education in chronic low back pain. Clin J Pain 2004; 20 (05) 324-330 doi:10.1097/00002508-200409000-00007
• 20 Nijs J, Meeus M, Cagnie B. et al. A modern neuroscience approach to chronic spinal pain: combining pain neuroscience education with cognition-targeted motor control training. Phys Ther 2014; 94 (05) 730-738 doi:10.2522/ptj.20130258
• 21 Traeger AC, Lee H, Markus Hübscher M. et al. Effect of Intensive Patient Education vs. Placebo Patient Education on Outcomes in Patients With Acute Low Back Pain: A Randomized Clinical Trial. JAMA Neurol 2019; 76 (02) 161-169 doi:10.1001/jamaneurol.2018.3376
• 22 Jeanmonod R, Luomajoki H. Welchen Anteil am therapeutischen Erfolg nimmt der Placebo Effekt bei der physiotherapeutischen Behandlung von Low Back Pain in Bezug auf die Schmerzen und die Rumpfbeweglichkeit ein? Ein quantitativer Versuch das Ausmass des Placebo Effekts in der Therapie von Low Back Pain festzulegen. Bachelor Arbeit 2010. Zürcher Hochschule für Angewandte Wissensschaften ZHAW: Winterthur; 2010