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Der Nuklearmediziner 2021; 44(02): 160-176
DOI: 10.1055/a-1393-7958
DOI: 10.1055/a-1393-7958
Aktuelle Trends aus den Radiopharmazeutischen Wissenschaften
Der Chemokinrezeptor CXCR4 – seine Entwicklung und Bedeutung in der nuklearmedizinischen Theranostik
Development and significance of the chemokine receptor CXCR4 for theranostics in nuclear medicine
Zusammenfassung
Der Chemokinrezeptor CXCR4 – häufig nachgewiesen, doch selten greifbar. Während in einer schier endlosen Zahl an Studien seine physiologische und pathogene Präsenz, seine zellulären Funktionen sowie Möglichkeiten seiner gezielten pharmakologischen Kontrolle seit fast 30 Jahren erforscht werden, ist das Spektrum seiner nuklearmedizinischen klinischen Anwendungen mit malignen Krankheitsbildern des hämatopoetischen Systems und einigen wenigen Entzündungsprozessen immer noch überschaubar. Das Verständnis um Prozesse, die seine dynamische Zelloberflächenexpression regulieren sowie die Suche nach selektiven Radiopharmaka zur Unterscheidung physiologischer von pathogenen CXCR4-Expressionen stellen die Herausforderung der Zukunft dar, um den CXCR4 als ein vielseitiges theranostisches Target in der Nuklearmedizin zu manifestieren.
Abstract
The chemokine receptor CXCR4 – frequently verified, rarely captured. For almost 30 years now, numerous investigations have addressed its physiological and pathological expression, its cellular functions, as well as pharmacological possibilities of its regulation. Still, applications targeting the CXCR4 in the field of nuclear medicine are limited. Reliable clinical imaging and therapy is restricted to hematopoietic diseases and only a few numbers of inflammatory processes. To make it a versatile platform for nuclear medical applications, future challenges are the expansion of knowledge about dynamic processes regulating the CXCR4 cell surface expression next to the development of selective radiopharmaceuticals that can distinguish between physiological and pathological CXCR4-expressions.
Publication History
Article published online:
10 June 2021
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