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Int J Sports Med 2021; 42(14): 1260-1267
DOI: 10.1055/a-1480-7692
Physiology & Biochemistry

Circulating MicroRNA Responses to Postprandial Lipemia with or without Prior Exercise

Catherine B. Springer
1   Department of Kinesiology, University of Maryland School of Public Health, College Park, United States
,
Ryan M. Sapp
1   Department of Kinesiology, University of Maryland School of Public Health, College Park, United States
,
William S. Evans
1   Department of Kinesiology, University of Maryland School of Public Health, College Park, United States
,
James M. Hagberg
1   Department of Kinesiology, University of Maryland School of Public Health, College Park, United States
,
Steven J. Prior
1   Department of Kinesiology, University of Maryland School of Public Health, College Park, United States
2   Department of Veterans Affairs, Baltimore Veterans Affairs Geriatric Research, Education and Clincial Center, Baltimore, United States
› Institutsangaben Funding: This research was supported by an American College of Sports Medicine Foundation grant and the University of Maryland Department of Kinesiology Graduate Research Initiative Fund. S.J.P. was supported, in part, by the Baltimore Veterans Affairs Medical Center Geriatric Research, Education, and Clinical Center.
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Abstract

Repeated exposure to a high-fat meal triggers inflammation and oxidative stress, contributing to the onset of cardiometabolic diseases. Regular exercise prevents cardiometabolic diseases and a prior bout of acute endurance exercise can counteract the detrimental cardiovascular effects of a subsequent high-fat meal. Circulating microRNAs (ci-miRs) are potential mediators of these vascular effects through regulation of gene expression at the posttranscriptional level. Therefore, we investigated the expression of ci-miRs related to vascular function (miR-21, miR-92a, miR-126, miR-146a, miR-150, miR-155, miR-181b, miR-221, miR-222) in plasma from healthy, recreationally to highly active, Caucasian adult men after a high-fat meal with (EX) and without (CON) a preceding bout of cycling exercise. Ci-miR-155 was the only ci-miR for which there was a significant interaction effect of high-fat meal and exercise (p=0.050). Ci-miR-155 significantly increased in the CON group at two (p=0.007) and four hours (p=0.010) after the high-fat meal test, whereas it significantly increased in the EX group only four hours after the meal (p=0.0004). There were significant main effects of the high-fat meal on ci-miR-21 (p=0.01), ci-miR-126 (p=0.02), ci-miR-146a (p=0.02), ci-miR-181b (p=0.02), and ci-miR-221 (p=0.008). Collectively, our results suggest that prior exercise does not prevent high-fat meal-induced increases in vascular-related ci-miRs.

Key words

microRNA - exercise - postprandial lipemia - vascular


Publikationsverlauf

Eingereicht: 11. Dezember 2020

Angenommen: 03. April 2021

Artikel online veröffentlicht:
11. Juni 2021

© 2021. Thieme. All rights reserved.

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Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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