Das Lynch-Syndrom als bedeutendes erbliches Tumorsyndrom

Neben demhereditären Brust- und Eierstockkrebssyndrom ist das Lynch-Syndrom das häufigste erbliche Tumorsyndrom mit kolorektalen, gynäkologischen sowie Manifestationen an weiteren Organsystemen. Die sorgfältige ärztliche (Familien-) Anamnese ist vor allem im Hinblick auf die Früherkennung der prognostisch ungünstigen Kolorektalkarzinome sehr wichtig. Für assoziierte gynäkologische Tumoren sind Checkpoint-Inhibitoren vielversprechende Therapeutika.

Publication History

Article published online:
25 November 2021

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