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Horm Metab Res 2023; 55(05): 367-373
DOI: 10.1055/a-2008-0905
Original Article: Endocrine Research

Clinical Diagnostic Values of C1q/TNF-Related Protein-3 for Polycystic Ovary Syndrome Women with Insulin Resistance

Manyin Zhao‡
1   Department of Gynecology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China
,
Yangyang Li‡
1   Department of Gynecology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China
,
Yifan Zhang‡
2   Department of Obstetrics, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China
,
Xiaojie Wang
1   Department of Gynecology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China
,
Xinshu Wang
1   Department of Gynecology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China
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Abstract

Polycystic ovary syndrome (PCOS) is the most common disease caused by complex endocrine and metabolic abnormalities in women. Insulin resistance is considered an important pathophysiological factor in the pathogenesis of PCOS. Here we investigated the clinical values of C1q/TNF-related protein-3 (CTRP3) as predictive factor for insulin resistance. Our study included 200 patients with PCOS, among which 108 had insulin resistance. Serum CTRP3 levels were measured using enzyme-linked immunosorbent assay. Predictive values of CTRP3 for insulin resistance was analyzed using receiver operating characteristic (ROC) analysis. Correlations of CTRP3 to insulin levels, obesity measurements and blood lipid levels were determined using Spearman’s correlation analysis. Our data suggested that PCOS patients with insulin resistance had a higher obesity, lower high-density lipoprotein cholesterol, higher total cholesterol, higher insulin levels and lower CTRP3 levels. CTRP3 had a high sensitivity (72.22%) and specificity (72.83%). CTRP3 significantly correlated to insulin levels, body mass index, waist-to-hip ratio, high-density lipoprotein, and total cholesterol levels. The predictive value of CTRP3 in PCOS patients with insulin resistance was supported by our data. Our findings suggest that CTRP3 is involved in the pathogenesis and insulin resistance of PCOS, which indicates its value as an indicator for the PCOS diagnosis.

Keywords

lipoprotein - obesity - metabolic syndrome - insulin resistance - diabetes - C1q/TNF-related protein-3


Publication History

Received: 06 September 2022

Accepted after revision: 15 December 2022

Article published online:
20 February 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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