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Horm Metab Res 1978; 10(1): 36-37
DOI: 10.1055/s-0028-1093477
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© Georg Thieme Verlag KG Stuttgart · New York

Urinary and Plasma Cyclic AMP Levels during Short Term Starvation in Obese Man: Response to Glucagon Stimulation

B. P. Turpin , M. W. Austin , S. S. Solomon
  • Medical and Research Services, Veterans Administration Hospital and Department of Medicine, University of Tennessee Center for the Health Sciences, Memphis T.N., U.S.A.
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Publication Date:
23 December 2008 (online)

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Abstract

Glucagon is known to elevate the intracellular concentration of cyclic AMP in the hepatocyte. The increase in intracellular cyclic AMP is reflected by an increase in the plasma concentration of the nucleotide. Intravenous glucagon stimulation was performed on six obese non-diabetic human subjects before and after a three day fast. All patients responded to starvation by a lowering of plasma immunoreactive insulin and blood glucose. Whereas the plasma immunoreactive glucagon concentration increased over the three day period, the plasma and urinary cyclic AMP did not significantly change. Intravenous glucagon promoted qualitatively similar increases in the blood glucose and plasma concentrations of insulin and cyclic AMP before and after three days starvation.

Key words

Starvation - Glucagon - Cyclic AMP

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