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Horm Metab Res 1978; 10(1): 58-61
DOI: 10.1055/s-0028-1093482
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© Georg Thieme Verlag KG Stuttgart · New York

Thyroxine-Binding Globulin, Triiodothyronine, Thyroxine and Thyrotropin in Newborn Infants and Children

P.  Stubbe , J.  Gatz , P.  Heidemann , A. v.z. Mühlen , R.  Hesch
  • Pediatric Department, University of Göttingen and Department of Endocrinology, University of Hannover, Germany
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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

Thyroxine-binding globulin (TBG), triiodothyronine (T3), thyroxine (T4) and thyrotropin (TSH) have been determined by radioimmunoassays in plasma of newborn infants and throughout childhood until puberty. Mean maternal TBG concentration was 1.65 ± 0.09 mg/100 ml (SEM) and significantly higher (p < 0.01) than cord blood levels of TBG (1.16 ± 0.08 mg/100 ml (SEM)). Throughout infancy and childhood TBG remained significantly elevated (p < 0.01) compared to a middle age control group of healthy blood donors. T3, T4 and TSH concentrations behaved postnatally as known from previous studies. The T3 and T4 increase observed immediately after birth was not a secondary phenomenon due to changes in TBG concentration since this globulin did not change significantly during this period.

Key words

Thyroxine-Binding Globulin - Triiodothyronine - Thyroxine - Thyrotropin - Newborns - Infancy - Childhood

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