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Horm Metab Res 1978; 10(1): 75-77
DOI: 10.1055/s-0028-1093486
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© Georg Thieme Verlag KG Stuttgart · New York

The Effect of Parathyroid Hormone and Vitamin D3 Metabolites on CaBP Synthesis by Embryonic Duodenum, In Vitro

C. O. Parkes , J. J. Reynolds
  • Department of Physiology, University of British Columbia, Canada and Strangeways Research Laboratory, Cambridge, England
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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

Embryonic chick duodena were incubated, in vitro, for two days in the presence of vitamin D analogues and metabolites and the ability of PTH to potentiate the vitamin-D-dependent synthesis of CaBP measured. PTH potentiated CaBP synthesis in the presence of vitamin D3, 25-OH-D3, 1α-OH-D3, DHT, and 1,25(OH)2D3. The synthesis of CaBP was directly related to the log of the medium PTH concentration over the range 1 × 10-8 M to 5 × 10-7M.

Key words

Vitamin D - Parathyroid Hormone - Calcium Binding Protein - Duodenum - Organ Culture

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