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Horm Metab Res 1977; 9(3): 228-231
DOI: 10.1055/s-0028-1093542
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© Georg Thieme Verlag KG Stuttgart · New York

Dose-Dependent Effect of TRH on Plasma Oleic Acid in Man

C.  Blum [*] , R.  Huron , J. P. Desager , C.  Harvengt
  • Laboratoire de Pathologie Générale, Faculté de Médecine, et Laboratoire de Statistique, Université Paul-Sabatier, Toulouse, France and
    Laboratoire de Pharmacothérapie, Université Catholique de Louvain, Belgique
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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

Administered to normal subjects of either sex, the TRH enhances the plasma oleic acid after 60 minutes without any significantly marked modification in the blood concentration of total FFA.

The oleic acid increase is significantly dependent on the amount of administered TRH (200 µg and ≥ 400 µg). It is accompanied by 1) a more or less pronounced but acute release of TSH, and 2) a rise in circulating T3 but a submaximal value within the time-course of the experiment (1 h).

This elevation is presumably due to a preferential liberation of oleic acid by the adipose tissue, through a direct action of TSH and/or under the permissive influence of the thyroid hormone, among other factors that may intervene in the process.

Key words

TRH - Human Blood - FFA - Oleic Acid - TSH - T3

1 Institut National de la Santé et de la Recherche Médicale (Inserm, Paris, France)

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