Download PDF
Exp Clin Endocrinol Diabetes 1983; 82(5): 235-237
DOI: 10.1055/s-0029-1210282
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Reversal of Acute Streptozotocin-Induced Glycemie Changes by Chemical Ventro-Medial Hypothalamic Lesions

T. D. Kimbrough, L. B. Weekley
  • Department of Biological Sciences, Virginia Commonwealth University, Richinomd, Va./U.S.A.
Further Information

Publication History

1982

Publication Date:
17 July 2009 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

This report describes the effect of chemical gold thioglucose (GTG) lesions of the ventromedial hypothalamic (VMH) nuclei in male Sprague-Dawley rats previously made diabetic by injection of streptozotocin (50 mg/kg, i.v.). Injection of streptozotocin resulted in hyperglycemia (blood glucose > 200 mg%) within one week; treatment of these rats with intracerebroventricular (ICV) injections of GTG (0.025 M) + Insulin (1 μU) reversed these glycemic changes within six weeks. On the basis of these initial experiments, it has been shown that GTG lesions of the VMH may reverse glycemic changes in acute streptozotocin-induced diabetes.

      >