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Exp Clin Endocrinol Diabetes 1985; 85(2): 245-248
DOI: 10.1055/s-0029-1210444
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Plasma Oxytocin Concentrations in Man after Different Routes of Administration of Synthetic Oxytocin

R. Landgraf
  • Section of Biosciences, Department of Cell Biology and Regulation (Head: Prof. Dr. A. Ermisch) of the Karl Marx University Leipzig/GDR
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Publication History

1984

Publication Date:
16 July 2009 (online)

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Summary

Plasma oxytocin was determined by RIA in three male subjects under basal conditions and following administration of synthetic oxytocin. As compared to basal levels (below 10pg/ml), plasma oxytocin was found to be elevated markedly (36 to 85 pg/ml) in response to application by nasal spray (total dose: 65 to 100 µg). Intramuscular injection (25 µg) resulted in very high oxytocin levels (360 to 480 pg/ml), whereas buccal administration (70 µg) was proved to be ineffective (levels below 10 pg/ml plasma). In each case, plasma vasopressin remained unchanged.

Key words

Oxytocin - vasopressin - radioimmunoassay - nasal spray

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