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Exp Clin Endocrinol Diabetes 1989; 94(4/05): 219-222
DOI: 10.1055/s-0029-1210901
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Splenopentin (DAc SP-5) — Accelerated Reconstitution of Antibody Formation after Syngeneic Bone Marrow Transplantation *)

R. Eckert, W. Diezel, R. Schmidt, K. Forner, H.-D. Volk
  • Institute of Medical Immunology and Department of Dermatology, Medical School (Charité), Humboldt University, Berlin, and Institute of Drug Research of the Academy of Sciences of the GDR, Berlin, GDR
*) Dedicated to Professor Dr. G. Dörner on the occasion of his 60th birthday.
Further Information

Publication History

1988

Publication Date:
16 July 2009 (online)

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Summary

Sublethally irradiated AB/Bln. mice (800 c Gy) and supplemented with syngeneic bone marrow cells were treated with or without a splenopentin derivative (DAc SP-5) and compared for their capacity to produce antibodies. In bone marrow cell plus DAc SP-5 treated animals antibody forming cells were found earlier and in a higher frequency than in mice treated with bone marrow cells only. These findings demonstrate that DAc SP-5 is able to induce bone marrow cell maturation.

Key words

Splenopentin - Bone marrow - Cell maturation

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