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Exp Clin Endocrinol Diabetes 1996; 104: 4-6
DOI: 10.1055/s-0029-1211668
Autoimmune thyroiditis-spontaneous disease models

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

The obese strain chicken as a model for human Hashimoto's thyroiditis

R. S. Sundick1 , N. Bagchi2 , T. R. Brown2
  • 1Department of Immunology and Microbiology, Wayne State University, Detroit, MI, USA
  • 2Department of Internal Medicine, Wayne State University, Detroit, MI, USA
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Publication History

Publication Date:
15 July 2009 (online)

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Summary

The OS and the related Cornell C strain are interesting animal models for the study of the etiology of autoimmune thyroiditis. They are especially valuable for studying the etiologic role of thyroid abnormalities and abnormalities in the processing of iodine. Limitations of the model are the scarcity of immunological reagents for chickens, the absence of avian cloned thyroid-specific genes, minimal amounts of microsomal antibody and some differences between OS chickens and Hashimoto's patients in the types of thyroid abnormalities observed.

Key words

Chickens - thyroid metabolic defects - autoimmune thyroiditis

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