Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000011.xml
Dtsch Med Wochenschr 2009; 134(16): 831-833
DOI: 10.1055/s-0029-1220239
DOI: 10.1055/s-0029-1220239
Kommentar | Commentary
Hämostaseologie
© Georg Thieme Verlag KG Stuttgart · New York
Neue Antikoagulantien
New anticoagulantsFurther Information
Publication History
eingereicht: 18.3.2009
akzeptiert: 2.4.2009
Publication Date:
07 April 2009 (online)
Schlüsselwörter
direkte Antikoagulation - Thrombininhibition - Faktor-Xa-Inhibition
Keywords
direct anticoagulation - thrombin inhibitor - factor Xa inhibition
Literatur
- 1 Agnelli G, Gallus A, Goldhaber S Z, Haas S, Huisman M V, Hull R D, Kakkar A K, Misselwitz F, Schellong S. ODIXa-DVT Study Investigators . Treatment of proximal deep-vein thrombosis with the oral direct factor Xa inhibitor rivaroxaban (BAY 59 – 7939): the ODIXa-DVT (Oral Direct Factor Xa Inhibitor BAY 59 – 7939 in Patients With Acute Symptomatic Deep-Vein Thrombosis) study. Circulation. 2007; 116 180-187
- 2 Buller H R, Lensing A W, Prins M H, Agnelli G, Cohen A, Gallus A S, Misselwitz F, Raskob G, Schellong S, Segers A. Einstein-DVT Dose-Ranging Study investigators . A dose-ranging study evaluating once-daily oral administration of the factor Xa inhibitor rivaroxaban in the treatment of patients with acute symptomatic deep vein thrombosis: the Einstein-DVT Dose-Ranging Study. Blood. 2008; 112 2242-2247
- 3 Eriksson B I, Borris L C, Friedman R J, Haas S, Huisman M V, Kakkar A K, Bandel T J, Beckmann H, Muehlhofer E, Misselwitz F, Geerts W. RECORD1 Study Group . Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty. New Engl J Med. 2008; 358 2765-2775
- 4 Eriksson B I, Dahl O E, Buller H R, Hettiarachchi R, Rosencher N, Bravo M L, Ahnfelt L, Piovella F, Stangier J, Kalebo P, Reilly P. BISTRO II Study Group . A new oral direct thrombin inhibitor, dabigatran etexilate, compared with enoxaparin for prevention of thromboembolic events following total hip or knee replacement: the BISTRO II randomized trial. Thrombos Haemost. 2005; 3 103-111
- 5 Eriksson B I, Dahl O E, Rosencher N, Kurth A A, van Dijk C N, Frostick S P, Prins M H, Hettiarachchi R, Hantel S, Schnee J, Buller H R. RE-NOVATE Study Group . Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement. Lancet. 2007; 370 949-956
- 6 Ezekowitz M D, Reilly P A, Nehmiz G, Simmers T A, Nagarakanti R, Parcham-Azad K, Pedersen K E, Lionetti D A, Stangier J, Wallentin L. Dabigatran with or without concomitant aspirin compared with warfarin alone in patients with nonvalvular atrial fibrillation (PETRO Study). Amer J Cardiol. 2007; 100 1419-1426
- 7 Hurlen M, Smith P, Arnesen H. Effects of warfarin, aspirin and the two combined, on mortality and thromboembolic morbidity after myocardial infarction. The WARIS-II (Warfarin-Aspirin Reinfarction Study) design. Scand Cardiovasc J. 2000; 34 168-171
- 8 Kakkar A K, Brenner B, Dahl O E, Eriksson B I, Mouret P, Muntz J, Soglian A G, Pap A F, Misselwitz F, Haas S. RECORD2 Investigators . Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty. Lancet. 2008; 372 31-39
- 9 Lassen M R, Ageno W, Borris L C, Lieberman J R, Rosencher N, Bandel T J, Misselwitz F, Turpie A G. RECORD3 Investigators . Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty. New Engl J Med. 2008; 358 2776-2786
- 10 Mueck W, Eriksson B I, Bauer K A, Borris L, Dahl O E, Fisher W D, Gent M, Haas S, Huisman M V, Kakkar A K, Kalebo P, Kwong L M, Misselwitz F, Turpie A G. Population pharmacokinetics and pharmacodynamics of rivaroxaban – an oral, direct factor Xa inhibitor – in patients undergoing major orthopaedic surgery. Clin Pharmacokinetics. 2008; 47 203-16
- 11 Smith P. Oral anticoagulants are effective long-term after acute myocardial infarction. J Intern Med. 1999; 245 383-7
- 12 Stangier J, Rathgen K, Stahle H, Gansser D, Roth W. The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Brit J Clin Pharmacol. 2007; 64 292-303
- 13 Wolowacz S E, Roskell N S, Plumb J M, Caprini J A, Eriksson B I. Efficacy and safety of dabigatran etexilate for the prevention of venous thromboembolism following total hip or knee arthroplasty. A meta-analysis. Thrombos Haemost. 2009; 101 77-85
Prof. Dr. med. H. Darius
Klinik für Innere Medizin, Kardiologie & konservative Intensivmedizin, Vivantes
Klinikum Neukölln
Rudower Str. 48
12351
Berlin
Email: harald.darius@vivantes.de