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Horm Metab Res 2010; 42(8): 590-594
DOI: 10.1055/s-0030-1253404
Humans, Clinical

© Georg Thieme Verlag KG Stuttgart · New York

Similar Associations of Total Adiponectin and High Molecular Weight Adiponectin with Cardio-metabolic Risk Factors in a Population of Overweight and Obese Postmenopausal Women: A MONET Study

B. Elisha1 , 2 , 3 , S. Ziai1 , 2 , 3 , A. D. Karelis4 , A. Rakel5 , 6 , L. Coderre2 , 7 , P. Imbeault8 , R. Rabasa-Lhoret1 , 2 , 3 , 5 , 6
  • 1Department of Nutrition, University of Montreal, Montreal, Quebec, Canada
  • 2Institut de Recherches Cliniques de Montréal (IRCM), Montreal, Quebec, Canada
  • 3Montreal Diabetes Research Center (MDRC), Montreal, Quebec, Canada
  • 4Department of Kinanthropology, University of Quebec at Montreal, Montreal, Quebec, Canada
  • 5Endocrinology Division, Department of Medicine, Centre Hospitalier de l’Université de Montréal, Montreal, Quebec, Canada
  • 6Centre de recherche du Centre Hospitalier de l’Université de Montréal, Montreal, Quebec, Canada
  • 7Department of Medicine, University of Montreal, Montreal, Quebec, Canada
  • 8School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada
Further Information

Publication History

received 22.12.2009

accepted 12.04.2010

Publication Date:
18 May 2010 (online)

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Abstract

The aim of the study was to examine the association between total adiponectin and high molecular weight (HMW) adiponectin levels with cardio-metabolic risk factors in a population of sedentary, overweight, and obese postmenopausal women. Cross-sectional study was carried out on 55 nondiabetic sedentary overweight and obese postmenopausal women aged between 50 and 70 years. Insulin sensitivity was assessed by euglycemic-hyperinsulinemic clamp technique. Body composition and visceral fat were measured using dual X-ray absorptiometry and computed tomography, respectively. Other cardio-metabolic risk factors included: plasma lipids, hsC-reactive protein, energy expenditure (doubly labeled water), peak oxygen consumption, muscle strength (using weight training equipment) as well as total and HMW adiponectin. Correlations of total and HMW adiponectin with various cardio-metabolic risk factors were comparable. In addition, regression analysis results showed similar independent predictors of total and HMW adiponectin. Finally, the receiver operator characteristic (ROC) curves for total and HMW adiponectin to predict insulin sensitivity showed no difference between the areas under curve (AUC) (AUC total adiponectin=0.80 [95% CI: 0.66–0.95] versus AUC HMW adiponectin=0.76 [95% CI: 0.60–0.91], p=0.36). The present study indicates that HMW adiponectin does not seem to provide additional information than total adiponectin in relation to cardio-metabolic risk factors in overweight/obese postmenopausal women.

Key words

insulin sensitivity - adipokines - body composition - lipid profile - inflammation - energy expenditure

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Correspondence

R. Rabasa-LhoretMD, PhD 

Institut de recherches cliniques

de Montréal (IRCM)

110, avenue Des Pins Ouest

Montréal

Québec H2W 1R7

Canada

Phone: +1/514/987 5668

Fax: +1/514/987 5670

Email: remi.rabasa-lhoret@ircm.qc.ca

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