Indikation zur Thrombozytentransfusion bei hämatologischen Patienten – weniger ist mehr!

Schlüsselwörter

Thrombozytopenie - Plättchenkonzentrate

Keywords

thrombocytopenia - platelet transfusion

Literatur

• 1 Empfehlungen zur Thrombozytentransfusion: Thrombozyten Arbeitsgruppe der DGTI, GTH und DGHO.  www.dgho.de/informationen/leitlinien/allgemeines-therapieverfahren/
• 2 Gaydos L A, Freirecht E J, Mantel N. The quantitative relation between platelet count and hemorrhage in patients with acute leukemia.  N Engl J Med. 1962;  266 905-909
• 3 Gmür J, Burger J, Schanz U. et al . Safety of stringent prophylactis platelet transfusion policy for patients with acute leukemia.  Lancet. 1991;  338 1223-1226
• 4 Heddle N M, Cook R J, Tinmouth A. et al . A randomized controlled trial comparing standard- and low-dose strategies for transfusion of platelets (STOP) to patients with thrombocytopenia.  Blood. 2009;  113 1564-1573
• 5 Leucocyte reduction and ultraviolet B irradiation of platelets to prevent alloimmunization and refractoriness to platelet transfusions. The Trail to Reduce Alloimmunization to Platelets Study Group.  N Engl J Med. 1997;  337 1861-1869
• 6 Querschnitts-Leitlinien zur Therapie mit Blutkomponenten und Plasmaderivaten; 2 Thrombozytenkonzentrate. Köln: Deutscher Ärzteverlag; 2009: 33-55
• 7 Sagmeister M, Oec L, Gmür J. A restrictive platelet transfusion policy allowing long-term support of outpatients with severe aplastic anemia.  Blood. 1999;  93 3124-3126
• 8 Slichter S J, Davis K, Enright H. et al . Factors affecting posttransfusion platelet increments, platelet refractoriness, and platelet transfusion intervals in thrombocytopenic patients.  Blood. 2005;  105 4106-4114
• 9 Slichter S J, Kaufmann R M, Assmann S F. et al . Dose of prophylactic platelet transfusions and prevention of hemorrhage.  N Engl J Med. 2010;  362 600-13
• 10 Schrezenmeier H, Seifried E. Buffy-coat-derived pooled platelet concentrates and apheresis platelet concentrates: which product type should be preferred?.  Vox Sang. 2010; Jan 4. Epub; 
• 11 Wandt H, Frank M, Ehninger G. et al . Safety and cost effectiveness of a 10x109/l trigger for prophylactic platelet transfusion compared with the traditional 20x109/l trigger: a prospective comparative trial in 105 patients with acute myeloid leukemia.  Blood. 1998;  91 3601-3606
• 12 Wandt H, Schaefer-Eckart K, Frank M. et al . A therapeutic platelet transfusion strategy is safe and feasible in patients after autologous peripheral blood stem cell transplantation.  Bone Marrow Transplant. 2006;  37 387-392