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Semin Thromb Hemost 2011; 37(2): 106-110
DOI: 10.1055/s-0030-1270335
© Thieme Medical Publishers

Thrombophilia and Pre-Eclampsia

Moniek P.M de Maat1 , Christianne J.M de Groot1
  • 1Department of Hematology, Erasmus University Medical Center, Rotterdam and Obstetrics and Gynaecology, VU University, Amsterdam, Medical Center, The Netherlands
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Publication History

Publication Date:
02 March 2011 (online)

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ABSTRACT

Pre-eclampsia (P-EC) poses an increased risk for fetal and maternal morbidity and sometimes even mortality. Several risk factors have been identified, among which an important extensively studied group is formed by the early recognizable genetic factors resulting in thrombophilia. The discussion is ongoing whether the associations found for thrombophilia are true and clinically relevant. In this review, we address the association between P-EC and thrombophilia, its concerns, and the necessity of screening after a pregnancy complicated by hypertension.

KEYWORDS

Thrombophilia - pre-eclampsia - genetic variation - polymorphism

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Moniek P.M de MaatPh.D. 

Department of Hematology, L-431, Erasmus MC

P.O. Box 2040, 3000 CA Rotterdam, The Netherlands

Email: m.demaat@erasmusmc.nl

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