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Exp Clin Endocrinol Diabetes 2011; 119(9): 536-539
DOI: 10.1055/s-0031-1279703
Article

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Increase in Energy Intake Leads to a Decrease in Obestatin in Restricting-Type of Anorexia Nervosa

M. Uehara1 , D. Yasuhara1 , T. Nakahara1 , T. Harada1 , K.-I. Koyama1 , M. Ushikai1 , A. Asakawa1 , A. Inui1
  • 1Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
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Publication History

received 08.02.2011 first decision 02.05.2011

accepted 06.05.2011

Publication Date:
10 June 2011 (online)

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Abstract

Restricting-type of anorexia nervosa (AN-R) is a serious disorder affecting adolescents and young adults, and decreases quality of life over long period. Successful weight restoration is an important prognostic factor for disease outcome; however, the underlying mechanism of refeeding-resistance, a core psychopathology relevant to ‘ambivalent’ eating behaviors, remains unclear in this disorder. Obestatin plays an important role in the regulation of growth hormone release, appetite, and energy metabolism. However, the progress of these patients and changes in the levels of obestatin during treatment were not reported. The purpose of this study was to determine the changes in obestatin levels when energy intake increases in AN-R patients. As a result, obestatin was higher in AN-R patients than in control subjects as well as acyl ghrelin and des-acyl ghrelin. An increase in the intake calorie has decreased obestatin as well as des-acyl ghrelin. These findings indicate that the obestatin is an important factor in the diagnosis and treatment of AN-R, similarly to acyl ghrelin and des-acyl ghrelin. In the future, the research on the clinical application of the ghrelin peptide family and the receptor will be expected to progress.

Key words

eating disorders - energy intake - hospitalization - gut hormone

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Correspondence

A. Asakawa

Department of Social and

Behavioral Medicine

Kagoshima University Graduate

School of Medical and Dental

Sciences

8–35–1 Sakuragaoka

890–8520 Kagoshima

Japan

Phone: +81/99/275 5751

Fax: +81/99/275 5749

Email: asakawa@m2.kufm.kagoshima-u.ac.jp

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