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Dtsch Med Wochenschr 2012; 137(14): 732-738
DOI: 10.1055/s-0031-1299037
Prinzip & Perspektive | Review article
Stammzellforschung
© Georg Thieme Verlag KG Stuttgart · New York

Regenerative Therapien bei fortgeschrittener Herzerkrankung

Regenerative treatment of advanced heart disease
D. M. Leistner
1   Medizinische Klinik III, Kardiologie, Klinikum der Goethe-Universität, Frankfurt/Main
,
F. H. Seeger
1   Medizinische Klinik III, Kardiologie, Klinikum der Goethe-Universität, Frankfurt/Main
,
S. Dimmeler
2   Institut für kardiovaskuläre Regeneration, Zentrum für Molekulare Medizin, Goethe-Universität, Frankfurt/Main
,
A. M. Zeiher
1   Medizinische Klinik III, Kardiologie, Klinikum der Goethe-Universität, Frankfurt/Main
,
B. Assmus
1   Medizinische Klinik III, Kardiologie, Klinikum der Goethe-Universität, Frankfurt/Main
› Author Affiliations
Further Information

Publication History

16 January 2012

08 March 2012

Publication Date:
27 March 2012 (online)

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Schlüsselwörter

Progenitorzelltherapie - Myokardinfarkt - Post-Infarkt-Herzinsuffizienz - Regenerative Medizin

Keywords

cell therapy - myocardial infarction - heart failure - regenerative medicine
 

  • Literatur

  • 1 Ang KL, Chin D, Leyva F et al. Randomized, controlled trial of intramuscular or intracoronary injection of autologous bone marrow cells into scarred myocardium during CABG versus CABG alone. Nat Clin Pract Cardiovasc Med 2008; 5: 663-670
    CrossrefPubMedGoogle Scholar
  • 2 Assmus B, Honold J, Schächinger V et al. Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med 2006; 355: 1222-1232
    CrossrefPubMedGoogle Scholar
  • 3 Bergmann O, Bhardwaj RD, Bernard S et al. Evidence for cardiomyocyte renewal in humans. Science 2009; 324: 98-102
    CrossrefPubMedGoogle Scholar
  • 4 Deb A, Wang S, Skelding KA et al. Bone marrow-derived cardiomyocytes are present in adult human heart: A study of gender-mismatched bone marrow transplantation patients. Circulation 2003; 107: 1247-1249
    CrossrefPubMedGoogle Scholar
  • 5 Gyöngyösi M, Lang I, Dettke M et al. Combined delivery approach of bone marrow mononuclear stem cells early and late after myocardial infarction: the MYSTAR prospective, randomized study. Nat Clin Pract Cardiovasc Med 2009; 6: 70-81
    CrossrefPubMedGoogle Scholar
  • 6 Hare JM, Traverse JH, Henry TD et al. A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. J Am coll Cardiol 2009; 54: 2277-2286
    CrossrefPubMedGoogle Scholar
  • 7 Hirsch A, Nijveldt R, van der Vleuten PA et al. Intracoronary infusion of mononuclear cells from bone marrow or peripheral blood compared with standard therapy in patients after acute myocardial infarction treated by primary percutaneous coronary intervention: results of the randomized controlled HEBE trial. Eur Heart J 2011; 32: 1736-1747
    CrossrefPubMedGoogle Scholar
  • 8 Huikuri HV, Kervinen K, Niemelä M et al. Effects of intracoronary injection of mononuclear bone marrow cells on left ventricular function, arrhythmia risk profile, and restenosis after thrombolytic therapy of acute myocardial infarction. Eur Heart J 2008; 29: 2723-2732
    CrossrefPubMedGoogle Scholar
  • 9 Janssens S, Dubois C, Bogaert J et al. Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial. Lancet 2006; 367: 113-121
    CrossrefPubMedGoogle Scholar
  • 10 Kissel CK, Lehmann R, Assmus B et al. Selective Functional Exhaustion of Hematopoietic Progenitor Cells in the Bone Marrow of Patients With Postinfarction Heart Failure. J Am Coll Cardiol 2007; 49: 2341-2349
    CrossrefPubMedGoogle Scholar
  • 11 Losordo DW, Schatz RA, White CJ et al. Intramyocardial Transplantation of Autologous CD34+ Stem Cells for Intractable Angina: A Phase I/IIa Double-Blind, Randomized Controlled Trial. Circulation 2007; 115: 3165-3172
    CrossrefPubMedGoogle Scholar
  • 12 Lunde K, Solheim S, Aakhus S et al. Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. N Engl J Med 2006; 355: 1199-1209
    CrossrefPubMedGoogle Scholar
  • 13 Martin-Puig S, Wang Z, Chien KR. Lives of a heart cell: tracing the origins of cardiac progenitors. Cell Stem Cell 2008; 2: 320-331
    CrossrefPubMedGoogle Scholar
  • 14 Menasché P, Alfieri O, Janssens S et al. The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation. Circualation 2008; 117: 1189-1200
    PubMedGoogle Scholar
  • 15 Mooney DJ, Vandenburgh H. Cell delivery mechanisms for tissue repair. Cell Stem Cell 2008; 2: 205-213
    CrossrefPubMedGoogle Scholar
  • 16 Pittenger MF, Martin BJ. Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res 2004; 95: 9-20
    CrossrefPubMedGoogle Scholar
  • 17 Pokushalov E, Romanov A, Chernyavsky A et al. Efficiency of intramyocardial injections of autologous bone marrow mononuclear cells in patients with ischemic heart failure: a randomized study. J Cardiovasc Transl Res 2010; 3 : 160-168
    PubMedGoogle Scholar
  • 18 Quaini F, Urbanek K, Beltrami AP et al. Chimerism of the transplanted heart. N Engl J Med 2002; 346: 5-15
    CrossrefPubMedGoogle Scholar
  • 19 Roncalli J, Mouquet F, Piot C et al. Intracoronary autologous mononucleated bone marrow cell infusion for acute myocardial infarction: results of the ranomized multicenter BONAMI trial. Eur Hear J 2011; 32: 1748-1757
    CrossrefPubMedGoogle Scholar
  • 20 Schächinger V, Erbs S, Elsässer A et al. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med 2006; 355: 1210-1221
    CrossrefPubMedGoogle Scholar
  • 21 Strauer BE, Brehm M, Zeus T et al. Intrakoronare, humane autologe Stammzelltransplantation zur Myokardregeneration nach Herzinfarkt. Dtsch med Wochenschr 2001; 126: 932-938
    Article in Thieme ConnectPubMedGoogle Scholar
  • 22 Taljaard M, Ward MR, Kutryk MJ et al. Rationale and design of Enhanced Angiogenic Cell Therapy in Acute Myocardial Infarction (ENACT-AMI): the first randomized placebo-controlled trial of enhanced progenitor cell therapy for acute myocardial infarction. A Heart J 2010; 159: 354-360
    PubMedGoogle Scholar
  • 23 Tendera M, Wojakowski W et al. Intracoronary infusion of bone marrow-derived selected CD34+CXCR4+ cells and non-selected mononuclear cells in patients with acute STEMI and reduced left ventricular ejection fraction: results of randomized, multicentre Myocardial Regeneration by Intracoronary Infusion of Selected Population of Stem Cells in Acute Myocardial Infarction (REGENT) Trial. Eur Heart J 2009; 30: 1313-1321
    CrossrefPubMedGoogle Scholar
  • 24 Tse H-F, Thambar S, Kwong Y-L et al. Prospective randomized trial of direct endomyocardial implantation of bone marrow cells for treatment of severe coronary artery diseases (PROTECT-CAD trial). European Heart J 2007; 28: 2998-3005
    CrossrefPubMedGoogle Scholar
  • 25 van Ramshorst J, Bax JJ, Beeres SL et al. Intramyocardial bone marrow cell injection for chronic myocardial ischemia: a randomized controlled trial. JAMA 2009; 301: 1997-2004
    CrossrefPubMedGoogle Scholar
  • 26 Wollert KC, Meyer GP, Lotz J et al. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet 2004; 364: 141-148
    CrossrefPubMedGoogle Scholar