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Horm Metab Res 2012; 44(11): 845-850
DOI: 10.1055/s-0032-1321759
Humans, Clinical
© Georg Thieme Verlag KG Stuttgart · New York

Serum Insulin-like Growth Factor I (IGF-I), IGF-Binding Proteins-1 and -3, and Postnatal Growth of Late Preterm Infants

V. I. Giapros
1   Neonatal Intensive Care Unit, University of Ioannina, Ioannina, Greece
,
V. Schiza
1   Neonatal Intensive Care Unit, University of Ioannina, Ioannina, Greece
,
A. S. Challa
2   Pediatric Research Laboratory, University of Ioannina, Ioannina, Greece
,
C. Pantou
1   Neonatal Intensive Care Unit, University of Ioannina, Ioannina, Greece
,
P. D. Theocharis
1   Neonatal Intensive Care Unit, University of Ioannina, Ioannina, Greece
,
S. K. Andronikou
1   Neonatal Intensive Care Unit, University of Ioannina, Ioannina, Greece
› Author Affiliations
Further Information

Publication History

received 13 January 2012

accepted 11 June 2012

Publication Date:
12 July 2012 (online)

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Abstract

Late preterm infants may have impaired early growth. The role of circulating insulin-like growth factors (IGFs) in the regulation of postnatal growth of these infants is unclear. The aim of the study was to investigate prospectively the serum levels of IGFs during the first year of life in late preterm infants and their association with birth weight and early postnatal growth. The study was conducted on 112 infants, born appropriate for gestational age (GA) at GA 32–36 weeks. Serum levels of IGF-I and IGF-binding proteins (IGFBP) -1 and -3, and anthropometric measurements were recorded at the chronological age of 2 and 6 weeks, and 3, 6, 9, and 12 months. The mean levels of both IGF-I and IGFBP-3 were found to be lower at 2 and 6 weeks, 82±44, 100±31 ng/ml, and 1.7±0.8, 2.1±1 μg/ml, respectively, but then rose and remained stable between 3 and 12 months. The levels of IGFBP-1 were lower at the 3 first study points and increased gradually thereafter. Birth weight correlated positively with the level IGF-I at 2 and 6 weeks (R=0.35, 0.37; p<0.01), but negatively at 12 months (R= − 0.34; p<0.01), independent of other factors. At all study points up to 6 months, the level of IGF-I was higher in infants who showed more rapid growth in either body weight or crown heel length. In late preterm infants, the serum IGF-I level is closely related to early accelerated growth. Its diverse associations with birth weight may imply a regulatory effect on regression of growth towards the mean.

Key words

IGF-I - IGFBP-3 - IGFBP-1 - accelerated growth - infant - late-preterm
 

  • References

  • 1 Le Roith D, Butler AAJ. Insulin-like Growth Factors in Pediatric Health and Disease. Clin Endocrinol Metab 1999; 84: 4355-4361
    PubMedGoogle Scholar
  • 2 Clemmons DR, Busby W, Clarke JB, Parker A, Duan C, Nam TJ. Modifications of insulin-like growth factor binding proteins and their role in controlling IGF actions. Endocr J 1998; 45 (Suppl. 01) S1-S8
    CrossrefPubMedGoogle Scholar
  • 3 Kajantie E, Hytinantti T, Koistinen R, Risteli J, Rutanen EM, Seppala M, Andersson S. Markers of type I and type III collagen turnover, insulin-like growth factors and their binding proteins in cord plasma of small premature infants: relationships with fetal growth, gestational age, preeclampsia, and antenatal glucocorticoid treatment. Pediatr Res 2001; 49: 481-489
    CrossrefPubMedGoogle Scholar
  • 4 Giudice LC, De Zegher F, Gargosky SE, Dsupin BA, de las Fuentes L, Crystal RA, Hintz RL, Rosenfeld RG. Insulin-like growth factors and their binding proteins in the term and preterm human fetus and neonate with normal and extremes of intrauterine growth. J Clin Endocrinol Metab 1995; 80: 1548-1555
    CrossrefPubMedGoogle Scholar
  • 5 Orbak Z, Darcan S, Coker M, Gökşen D. Maternal and fetal serum insulin-like growth factor-I (IGF-I) IGF binding protein-3 (IGFBP-3), leptin levels and early postnatal growth in infants born asymmetrically small for gestational age. J Pediatr Endocrinol Metab 2001; 14: 1119-1127
    PubMedGoogle Scholar
  • 6 Vatten LJ, Nilsen ST, Odegård RA, Romundstad PR, Austgulen R. Insulin-like growth factor I and leptin in umbilical cord plasma and infant birth size at term. Pediatrics 2002; 109: 1131-1135
    CrossrefPubMedGoogle Scholar
  • 7 Ozkan H, Aydin A, Demir N, Erci T, Büyükgebiz A. Associations of IGF-I, IGFBP-1 and IGFBP-3 on intrauterine growth and early catch-up growth. Biol Neonate 1999; 76: 274-282
    CrossrefPubMedGoogle Scholar
  • 8 Leger J, Noel M, Limal JM, Czernichow P. Growth factors and intrauterine growth retardation. II. Serum growth hormone, insulin-like growth factor-I, and IGF-binding protein-3 levels in children with intrauterine growth retardation compared with normal control subjects: prospective study from birth to two years of age. Pediatr Res 1996; 40: 101-107
    CrossrefPubMedGoogle Scholar
  • 9 Cianfarani S, Germani D, Rossi P, Rossi L, Germani A, Ossicini C, Zuppa A, Argiro G, Holly JM, Branca F. Intrauterine growth retardation: evidence for the activation of the insulin-like growth factor (IGF)-related growth-promoting machinery and the presence of a cation-independent IGF binding protein-3 proteolytic activity by two months of life. Pediatr Res 1998; 44: 374-380
    CrossrefPubMedGoogle Scholar
  • 10 Chellakooty M, Juul A, Boisen KA, Damgaard IN, Kai CM, Schmidt IM, Petersen JH, Skakkebaek NE, Main KM. A prospective study of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 in 942 healthy infants: associations with birth weight, gender, growth velocity, and breastfeeding. J Clin Endocrinol Metab 2006; 91: 820-826
    PubMedGoogle Scholar
  • 11 Ong KK, Langkamp M, Ranke MB, Whitehead K, Hughes IA, Acerini CL, Dunger DB. Insulin-like growth factor I concentrations in infancy predict differential gains in body length and adiposity: the Cambridge Baby Growth Study. Am J Clin Nutr 2009; 90: 156-161
    CrossrefPubMedGoogle Scholar
  • 12 Rajaram S, Carlson SE, Koo WW, Rangachari A, Kelly DP. Insulin-like growth factor (IGF)-I and IGF-binding protein 3 during the first year in term and preterm infants. Pediatr Res 1995; 37: 581-585
    CrossrefPubMedGoogle Scholar
  • 13 Juul A, Dalgaard P, Blum WF, Bang P, Hall K, Michaelsen KF, Muller J, Skakkebæk NE. Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation. J Clin Endocrinol Metab 1995; 80: 2534-2542
    CrossrefPubMedGoogle Scholar
  • 14 Low LC, Tam SY, Kwan EY, Tsang AM, Karlberg J. Onset of significant GH dependence of serum IGF-I and IGF-binding protein 3 concentrations in early life. Pediatr Res 2001; 50: 737-742
    CrossrefPubMedGoogle Scholar
  • 15 Engle WA, Tomashek KM, Wallman C. Committee on Fetus and Newborn, American Academy of Pediatrics. “Late-Preterm” Infants: A Population at Risk. Pediatrics 2007; 120: 1390-1401 Erratum in: Pediatrics 2008; 121: 451
    CrossrefPubMedGoogle Scholar
  • 16 Santos IS, Matijasevich A, Domingues MR, Barros AJ, Victora CG, Barros FC. Late preterm birth is a risk factor for growth faltering in early childhood: a cohort study. BMC Pediatr 2009; 9: 71
    CrossrefPubMedGoogle Scholar
  • 17 Gunnell D, Miller LL, Rogers I, Holly JM. ALSPAC Study Team. Association of insulin-like growth factor I and insulin-like growth factor-binding protein-3 with intelligence quotient among 8- to 9-year-old children in the Avon longitudinal study of parents and children. Pediatrics 2005; 116: e681-e686
    CrossrefPubMedGoogle Scholar
  • 18 Alexander GR, Kogan MD, Himes JH. 1994–1996 U.S. singleton birth weight percentiles for gestational age by race, Hispanic origin, and gender. Matern Child Health J 1999; 3: 225-231
    CrossrefPubMedGoogle Scholar
  • 19 Ong KK, Ahmed ML, Emmett PM, Preece MA, Dunger DB. Association between postnatal accelerated growth and obesity in childhood: prospective cohort study. BMJ 2000; 320: 967-971
    CrossrefPubMedGoogle Scholar
  • 20 Altman D. Practical Statistics for Medical Research. London: Chapman and Hall; 1991: 456-460
    Google Scholar
  • 21 Kajantie E, Dunkel L, Rutanen EM, Seppälä M, Koistinen R, Sarnesto A, Andersson S. IGF-I, IGF binding protein (IGFBP)-3, phosphoisoforms of IGFBP-1, and postnatal growth in very low birth weight infants. J Clin Endocrinol Metab 2002; 87: 2171-2179
    CrossrefPubMedGoogle Scholar
  • 22 Engström E, Niklasson A, Wikland KA, Ewald U, Hellström A. The role of maternal factors, postnatal nutrition, weight gain, and gender in regulation of serum IGF-I among preterm infants. Pediatr Res 2005; 57: 605-610
    CrossrefPubMedGoogle Scholar
  • 23 Ohkawa N, Shoji H, Kitamura T, Suganuma H, Yoshikawa N, Suzuki M, Lee T, Hisata K, Shimizu T. IGF-I, leptin and active ghrelin levels in very low birth weight infants during the first 8 weeks of life. Acta Paediatr 2010; 99: 37-41
    PubMedGoogle Scholar
  • 24 Baumann G. Growth hormone binding protein 2001. J Pediatr Endocrinol Metab. 2001 14. 355-375
    PubMedGoogle Scholar
  • 25 Ong KK, Elmlinger M, Jones R, Emmett P, ALSPAC Study Team. Holly J, Ranke MB, Dunger DB. Growth hormone binding protein levels in children are associated with birth weight, postnatal weight gain, and insulin secretion. Metabolism 2007; 56: 1412-1417
    CrossrefPubMedGoogle Scholar
  • 26 Hoppe C, Molgaard C, Thomsen BL, Juul A, Michaelsen KF. Protein intake at 9 mo of age is associated with body size but not with body fat in 10-y-old Danish children. Am J Clin Nutr 2004; 79: 494-501
    PubMedGoogle Scholar
  • 27 Geary MP, Pringle PJ, Rodeck CH, Kingdom JC, Hindmarsh PC. Sexual Dimorphism in the Growth Hormone and Insulin-Like Growth. J Clin Endocrinol Metab 2003; 88: 3708-3714
    CrossrefPubMedGoogle Scholar
  • 28 Setia S, Sridhar MG. Changes in GH/IGF-1 axis in intrauterine growth retardation: consequences of fetal programming?. Horm Metab Res 2009; 41: 791-798
    Article in Thieme ConnectPubMedGoogle Scholar