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Horm Metab Res 2014; 46(07): 521-527
DOI: 10.1055/s-0034-1368712
Endocrine Care
© Georg Thieme Verlag KG Stuttgart · New York

Acute Post-Exercise Oxygen Uptake, Hormone and Plasma Metabolite Response in Obese Men

S. Lanzi
1   Institute of Sport Sciences University of Lausanne (ISSUL), University of Lausanne, Lausanne, Switzerland
2   Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland
,
F. Codecasa
3   Pulmonary Rehabilitation Department, San Giuseppe Hospital, Istituto ­Auxologico Italiano Piancavallo, Verbania, Italy
,
M. Cornacchia
3   Pulmonary Rehabilitation Department, San Giuseppe Hospital, Istituto ­Auxologico Italiano Piancavallo, Verbania, Italy
,
S. Maestrini
4   Molecolar biology laboratory, San Giuseppe Hospital, Istituto Auxologico Italiano Piancavallo, Verbania, Italy
,
A. Salvadori
3   Pulmonary Rehabilitation Department, San Giuseppe Hospital, Istituto ­Auxologico Italiano Piancavallo, Verbania, Italy
,
P. Fanari
3   Pulmonary Rehabilitation Department, San Giuseppe Hospital, Istituto ­Auxologico Italiano Piancavallo, Verbania, Italy
,
A. Brunani
5   Medicine Rehabilitation Department, San Giuseppe Hospital, Istituto ­Auxologico Italiano Piancavallo, Verbania, Italy
,
D. Malatesta
1   Institute of Sport Sciences University of Lausanne (ISSUL), University of Lausanne, Lausanne, Switzerland
2   Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland
› Author Affiliations
Further Information

Publication History

received 22 October 2013

accepted 20 January 2014

Publication Date:
13 March 2014 (online)

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Abstract

This study aimed to compare oxygen uptake (  V˙O2), hormone and plasma metabolite responses during the 30 min after submaximal incremental exercise (Incr) performed at the same relative/absolute exercise intensity and duration in lean (L) and obese (O) men. Eight L and 8 O men (BMI: 22.9±0.4; 37.2±1.8 kg · m−2) completed Incr and were then seated for 30 min.   V˙O2 was monitored during the first 10 min and from the 25–30th minutes of recovery. Blood samples were drawn for the determination of hormone (catecholamines, insulin) and plasma metabolite (NEFA, glycerol) concentrations. Excess post-exercise oxygen consumption (EPOC) magnitude during the first 10 min was similar in O and in L (3.5±0.4; 3.4±0.3 liters, respectively, p=0.86). When normalized to percent change (  V˙O2END=100%), %   V˙O2END during recovery was significantly higher from 90–120 s in O than in L (p≤0.04). There were no significant differences in catecholamines (p≥0.24), whereas insulin was significantly higher in O than in L during recovery (p=0.01). The time-course of glycerol was similar from 10–30 min of recovery (−42% for L; –41% for O, p=0.85), whereas significantly different patterns of NEFA were found from 10–30 min of recovery between groups (−18% for L; +8% for O, p=0.03). Despite similar EPOC, a difference in   V˙O2 modulation between groups was observed, likely due to faster initial rates of   V˙O2 decline in L than in O. The different patterns of NEFA between groups may suggest a lower NEFA reesterification during recovery in O, which was not involved in the rapid EPOC component.

Key words

energy expenditure - physical activity - weight management - indirect calorimetry
 

  • References

  • 1 Borsheim E, Bahr R. Effect of exercise intensity, duration and mode on post-exercise oxygen consumption. Sports Med 2003; 33: 1037-1060
    CrossrefPubMedGoogle Scholar
  • 2 Gore CJ, Withers RT. Effect of exercise intensity and duration on postexercise metabolism. J Appl Physiol 1990; 68: 2362-2368
    CrossrefPubMedGoogle Scholar
  • 3 LaForgia J, Withers RT, Gore CJ. Effects of exercise intensity and duration on the excess post-exercise oxygen consumption. J Sports Sci 2006; 24: 1247-1264
    CrossrefPubMedGoogle Scholar
  • 4 Larsen I, Welde B, Martins C, Tjonna AE. High- and moderate-intensity aerobic exercise and excess post-exercise oxygen consumption in men with metabolic syndrome. Scand J Med Sci Sports. 2013 DOI: 10.1111/sms.12132
    PubMedGoogle Scholar
  • 5 Chad KE, Quigley BM. Exercise intensity: effect on postexercise O2 uptake in trained and untrained women. J Appl Physiol 1991; 70: 1713-1719
    PubMedGoogle Scholar
  • 6 Frey GC, Byrnes WC, Mazzeo RS. Factors influencing excess postexercise oxygen consumption in trained and untrained women. Metabolism 1993; 42: 822-828
    CrossrefPubMedGoogle Scholar
  • 7 Short KR, Sedlock DA. Excess postexercise oxygen consumption and recovery rate in trained and untrained subjects. J Appl Physiol 1997; 83: 153-159
    CrossrefPubMedGoogle Scholar
  • 8 Wong T, Harber V. Lower excess postexercise oxygen consumption and altered growth hormone and cortisol responses to exercise in obese men. J Clin Endocrinol Metab 2006; 91: 678-686
    CrossrefPubMedGoogle Scholar
  • 9 Gustafson AB, Farrell PA, Kalkhoff RK. Impaired plasma catecholamine response to submaximal treadmill exercise in obese women. Metabolism 1990; 39: 410-417
    CrossrefPubMedGoogle Scholar
  • 10 Borsheim E, Lonnroth P, Knardahl S, Jansson PA. No difference in the lipolytic response to beta-adrenoceptor stimulation in situ but a delayed increase in adipose tissue blood flow in moderately obese compared with lean men in the postexercise period. Metabolism 2000; 49: 579-587
    CrossrefPubMedGoogle Scholar
  • 11 Vettor R, Macor C, Rossi E, Piemonte G, Federspil G. Impaired counterregulatory hormonal and metabolic response to exhaustive exercise in obese subjects. Acta Diabetol 1997; 34: 61-66
    CrossrefPubMedGoogle Scholar
  • 12 World Health Organisation . Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: report of a WHO/IDF. Consultation 2006; 1-50
    PubMedGoogle Scholar
  • 13 Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419
    Google Scholar
  • 14 Lukaski HC, Bolonchuk WW, Hall CB, Siders WA. Validation of tetrapolar bioelectrical impedance method to assess human body composition. J Appl Physiol 1986; 60: 1327-1332
    PubMedGoogle Scholar
  • 15 Piccoli A, Brunani A, Savia G, Pillon L, Favaro E, Berselli ME, Cavagnini F. Discriminating between body fat and fluid changes in the obese adult using bioimpedance vector analysis. Int J Obes Relat Metab Disord 1998; 22: 97-104
    CrossrefPubMedGoogle Scholar
  • 16 Baumgartner RN, Ross R, Heymsfield SB. Does adipose tissue influence bioelectric impedance in obese men and women?. J Appl Physiol 1998; 84: 257-262
    PubMedGoogle Scholar
  • 17 Perez-Martin A, Dumortier M, Raynaud E, Brun JF, Fedou C, Bringer J, Mercier J. Balance of substrate oxidation during submaximal exercise in lean and obese people. Diabetes Metab 2001; 27: 466-474
    PubMedGoogle Scholar
  • 18 Billat VL, Mille-Hamard L, Demarle A, Koralsztein JP. Effect of training in humans on off- and on-transient oxygen uptake kinetics after severe exhausting intensity runs. Eur J Appl Physiol 2002; 87: 496-505
    CrossrefPubMedGoogle Scholar
  • 19 Ozyener F, Rossiter HB, Ward SA, Whipp BJ. Influence of exercise intensity on the on- and off-transient kinetics of pulmonary oxygen uptake in humans. J Physiol 2001; 533: 891-902
    CrossrefPubMedGoogle Scholar
  • 20 Frayn KN. Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 1983; 55: 628-634
    PubMedGoogle Scholar
  • 21 Lafontan M, Langin D. Lipolysis and lipid mobilization in human adipose tissue. Prog Lipid Res 2009; 48: 275-297
    CrossrefPubMedGoogle Scholar
  • 22 Brehm BA, Gutin B. Recovery energy expenditure for steady state exercise in runners and nonexercisers. Med Sci Sports Exerc 1986; 18: 205-210
    PubMedGoogle Scholar
  • 23 Sedlock DA. Fitness level and postexercise energy expenditure. J Sports Med Phys Fitness 1994; 34: 336-342
    PubMedGoogle Scholar
  • 24 Sedlock DA, Lee MG, Flynn MG, Park KS, Kamimori GH. Excess postexercise oxygen consumption after aerobic exercise training. Int J Sport Nutr Exerc Metab 2010; 20: 336-349
    CrossrefPubMedGoogle Scholar
  • 25 Fukuoka Y, Grassi B, Conti M, Guiducci D, Sutti M, Marconi C, Cerretelli P. Early effects of exercise training on on- and off-kinetics in 50-year-old subjects. Pflugers Arch 2002; 443: 690-697
    CrossrefPubMedGoogle Scholar
  • 26 Hagberg JM, Hickson RC, Ehsani AA, Holloszy JO. Faster adjustment to and recovery from submaximal exercise in the trained state. J Appl Physiol 1980; 48: 218-224
    PubMedGoogle Scholar
  • 27 Webber J, Macdonald IA. Metabolic actions of catecholamines in man. Baillieres Clin Endocrinol Metab 1993; 7: 393-413
    CrossrefPubMedGoogle Scholar
  • 28 Bahr R, Hostmark AT, Newsholme EA, Gronnerod O, Sejersted OM. Effect of exercise on recovery changes in plasma levels of FFA, glycerol, glucose and catecholamines. Acta Physiol Scand 1991; 143: 105-115
    CrossrefPubMedGoogle Scholar
  • 29 Mulla NA, Simonsen L, Bulow J. Post-exercise adipose tissue and skeletal muscle lipid metabolism in humans: the effects of exercise intensity. J Physiol 2000; 524 (Pt 3) 919-928
    CrossrefPubMedGoogle Scholar
  • 30 Wolfe RR, Klein S, Carraro F, Weber JM. Role of triglyceride-fatty acid cycle in controlling fat metabolism in humans during and after exercise. Am J Physiol 1990; 258: E382-E389
    PubMedGoogle Scholar
  • 31 Lafontan M, Moro C, Berlan M, Crampes F, Sengenes C, Galitzky J. Control of lipolysis by natriuretic peptides and cyclic GMP. Trends Endocrinol Metab 2008; 19: 130-137
    CrossrefPubMedGoogle Scholar
  • 32 Blaak EE, Van Baak MA, Kemerink GJ, Pakbiers MT, Heidendal GA, Saris WH. Beta-adrenergic stimulation of energy expenditure and forearm skeletal muscle metabolism in lean and obese men. Am J Physiol 1994; 267: E306-E315
    PubMedGoogle Scholar
  • 33 Salvadori A, Fanari P, Marzullo P, Codecasa F, Tovaglieri I, Cornacchia M, Brunani A, Luzi L, Longhini E. Short bouts of anaerobic exercise increase non-esterified fatty acids release in obesity. Eur J Nutr 2013; DOI: 10.1007/s00394-013-0522-x.
    PubMedGoogle Scholar
  • 34 Bonen A, Parolin ML, Steinberg GR, Calles-Escandon J, Tandon NN, Glatz JF, Luiken JJ, Heigenhauser GJ, Dyck DJ. Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36. Faseb J 2004; 18: 1144-1146
    PubMedGoogle Scholar
  • 35 LeCheminant JD, Jacobsen DJ, Bailey BW, Mayo MS, Hill JO, Smith BK, Donnelly JE. Effects of long-term aerobic exercise on EPOC. Int J Sports Med 2008; 29: 53-58
    Article in Thieme ConnectPubMedGoogle Scholar
  • 36 Yoshioka M, Doucet E, St-Pierre S, Almeras N, Richard D, Labrie A, Despres JP, Bouchard C, Tremblay A. Impact of high-intensity exercise on energy expenditure, lipid oxidation and body fatness. Int J Obes Relat Metab Disord 2001; 25: 332-339
    CrossrefPubMedGoogle Scholar
  • 37 Malatesta D, Werlen C, Bulfaro S, Cheneviere X, Borrani F. Effect of high-intensity interval exercise on lipid oxidation during postexercise recovery. Med Sci Sports Exerc 2009; 41: 364-374
    PubMedGoogle Scholar
  • 38 Bordenave S, Metz L, Flavier S, Lambert K, Ghanassia E, Dupuy AM, Michel F, Puech-Cathala AM, Raynaud E, Brun JF, Mercier J. Training-induced improvement in lipid oxidation in type 2 diabetes mellitus is related to alterations in muscle mitochondrial activity. Effect of endurance training in type 2 diabetes. Diabetes Metab 2008; 34: 162-168
    CrossrefPubMedGoogle Scholar
  • 39 Venables MC, Jeukendrup AE. Endurance training and obesity: effect on substrate metabolism and insulin sensitivity. Med Sci Sports Exerc 2008; 40: 495-502
    CrossrefPubMedGoogle Scholar
  • 40 Henderson GC, Fattor JA, Horning MA, Faghihnia N, Johnson ML, Mau TL, Luke-Zeitoun M, Brooks GA. Lipolysis and fatty acid metabolism in men and women during the postexercise recovery period. J Physiol 2007; 584: 963-981
    CrossrefPubMedGoogle Scholar