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Neuropediatrics 2015; 46(03): 211-220
DOI: 10.1055/s-0035-1548673
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Prognostic Value of Continuous Electroencephalography Monitoring in Children with Severe Brain Damage

Yan-huai Lan
1   Department of Neurology, Children's Hospital of Fudan University, Shanghai, China
*   These authors contributed equally to this study and they share first authorship.
,
Xiao-mei Zhu
1   Department of Neurology, Children's Hospital of Fudan University, Shanghai, China
*   These authors contributed equally to this study and they share first authorship.
,
Yuan-feng Zhou
1   Department of Neurology, Children's Hospital of Fudan University, Shanghai, China
,
Peng-ling Qiu
1   Department of Neurology, Children's Hospital of Fudan University, Shanghai, China
,
Guo-ping Lu
2   Department of Intensive Care Unit, Children's Hospital of Fudan University, Shanghai, China
,
Dao-kai Sun
1   Department of Neurology, Children's Hospital of Fudan University, Shanghai, China
,
Yi Wang
1   Department of Neurology, Children's Hospital of Fudan University, Shanghai, China
› Author Affiliations
Further Information

Publication History

25 January 2015

01 September 2014

Publication Date:
28 April 2015 (online)

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Abstract

Purpose The purpose of this study is to determine whether there is a relationship between continuous electroencephalography (EEG) monitoring patterns and prognosis for children with severe brain damage.

Patients and Methods The different patterns of EEG were analyzed for 103 children (Glasgow Coma Scale [GCS] score < 8) who were monitored with continuous video-EEG (CVEEG) within 72 hours after the onset of coma. The clinical outcomes were scored and evaluated at hospital discharge by the modified Pediatric Cerebral and Overall Performance Category Scale (PCOPCS). EEG parameters of the different prognosis groups were compared and risk factors for prognosis were identified.

Results Of the 103 children, 36 were in the good prognosis group (PCOPCS scores 1 and 2) and 67 were in the poor prognosis group (PCOPCS scores 3–6). The poor prognosis group had the lower proportion of events in reactive EEG patterns and sleep architecture, and a higher proportion of low-voltage events. Multivariate analyses showed that the lower GCS score and no sleep architecture were significantly associated with poor prognosis.

Conclusions Comatose children with higher GCS score and sleep architecture have better clinical outcomes in terms of morbidity and mortality.

Keywords

continuous electroencephalography - severe brain damage - prognosis - children
 

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