Download PDF
Thromb Haemost 1998; 80(06): 894-898
DOI: 10.1055/s-0037-1615384
Letters to the Editor
Schattauer GmbH

Tissue Factor Expression and Metastatic Potential of Colorectal Cancer

Chika Shigemori
1   Department of Surgery II
,
Hideo Wada
2   Department of Internal Medicine II, Mie University Medical School, Tsu, Japan
,
Kouichi Matsumoto
1   Department of Surgery II
,
Hiroshi Shiku
2   Department of Internal Medicine II, Mie University Medical School, Tsu, Japan
,
Shin Nakamura
3   Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University, Inuyama, Japan
,
Hiroshi Suzuki
1   Department of Surgery II
› Author Affiliations
Further Information

Publication History

Received 13 May 1998

Accepted after revision 17 August 1998

Publication Date:
07 December 2017 (online)

    Permissions and Reprints

Summary

Several studies have previously demonstrated tissue factor (TF) expression in solid tumors. In our study, we evaluated by immunohistochemical staining TF expression in 79 cases of colorectal cancer and 17 cases of metastatic cancer of the liver from colorectal cancer, and investigated the relationship between the clinicopathological features and TF expression.

TF was detected in the tumor of 57% of colorectal cancer patients, and its expression was significantly increased (p = 0.01) in metastatic tumors (88%). TF expression was more commonly observed in meta-static tumors than in any Dukes’ stage of primary cancer. In primary cancer, the detection of TF was more frequent in cases with lymph node metastasis (Dukes’ C, 63%) or with hematogenous metastasis (Dukes’ D, 82%) than in tumors without lymph node or hematogenous metastasis (Dukes’ A and B, 46%, p = 0.03).

These results suggest that the expression of TF is related with the metastatic potential of colorectal cancer.

 

  • References

  • 1 Nemerson Y. Tissue factor and hemostasis.. Blood 1988; 71: 1-8.
    PubMedGoogle Scholar
  • 2 Edgington TS, Mackman N, Brand K, Ruf S. Structural biology of expression and function of tissue factor.. Thromb Haemost 1991; 66: 67-79.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 3 Drake TA, Morrissey JH, Edgington TS. Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis.. Am J Pathol 1989; 134: 1087-97.
    PubMedGoogle Scholar
  • 4 Fleck RA, Rao LV, Rapaport SI, Varki N. Localization of human tissue factor antigen by immunostaining with monospecific polyclonal anti-human tissue factor antibody.. Thromb Res 1990; 59: 421-37.
    CrossrefPubMedGoogle Scholar
  • 5 Gralnick HR, Abrell E. Studies of the procoagulant and fibrinolytic activity of promyelocytes in acute promyelocytic leukemia.. Br J Haematol 1973; 24: 89-99.
    CrossrefPubMedGoogle Scholar
  • 6 Wada H, Nagano T, Tomeoku M, Kuto M, Karitani Y, Deguchi K, Shirakawa S. Coagulant and fibrinolytic activities in the leukemic cells lysates.. Thromb Res 1983; 30: 315-22.
    CrossrefPubMedGoogle Scholar
  • 7 Callander NS, Varki N, Rao LV. Immunohistochemical identification of tissue factor in solid tumors.. Cancer 1992; 70: 1194-201.
    CrossrefPubMedGoogle Scholar
  • 8 Kakkar AK, Lemoine NR, Scully MF, Tebbutt S, Williamson RC. Tissue factor expression correlates with histological grade in human pancreatic cancer.. Br J Surg 1995; 82: 1101-4.
    CrossrefPubMedGoogle Scholar
  • 9 Hamada K, Kuratsu J, Saitoh Y, Nishi T, Ushio Y. Expression of tissue factor correlates with of grade of malignancy in human glioma.. Cancer 1996; 77: 1877-83.
    CrossrefPubMedGoogle Scholar
  • 10 Sturm U, Luther T, Albrecht S, Flossel C, Grossmann H, Muller M. Immunohistological detection of tissue factor in normal and abnormal human mammary glands using monoclonal antibodies. Virchows Archv.. A Pathological Anatomy and Histopathology 1992; 421: 79-86.
    PubMedGoogle Scholar
  • 11 Higure A, Okamoto K, Hirata K, Todoroki H, Nagafuchi Y, Takeda S, Katoh H, Itoh H, Ohsato K, Nakamura S. Macrophages and neutrophils infiltrating into the liver are responsible for tissue factor expression in a rabbit model of acute obstructive cholangitis.. Thromb Haemost 1996; 75: 791-5.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 12 Mueller BM, Reisfeld RA, Edgington TS, Ruf W. Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis.. Proc Natl Acad Sci USA 1992; 89: 11832-6.
    CrossrefPubMedGoogle Scholar
  • 13 Bromberg ME, Konigsberg WH, Madisons JF, Pawashe A, Garen A. Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation.. Proc Natl Acad Sci USA 1995; 92: 8205-9.
    CrossrefPubMedGoogle Scholar
  • 14 Fischer EG, Ruf W, Mueller BM. Tissue factor-initiated thrombin generation activates the signaling thrombin receptor on malignant melanoma cells.. Cancer Res 1995; 55: 1629-32.
    PubMedGoogle Scholar
  • 15 Zhang Y, Deng Y, Luther T, Muller M, Ziegler R, Waldherr R, Stern DM, Nawroth PP. Tissue factor controls the balance of angiogenic and angiogenic propaties of tumor cells in mice.. J Clin Invest 1994; 94: 1320-7.
    CrossrefPubMedGoogle Scholar
  • 16 Nakamura S, Goto A, Takemoto S, Mizuguchi J, Funatsu A. Monoclonal antibodies to human tissue factor.. Thromb Haemost 1991; 65: 1216 (Abstract).
    PubMedGoogle Scholar
  • 17 Imamura T, Iyama K, Takeya M, Kambara T, Nakamura S. Role of macrophage tissue factor in the development of the delayed hypersensitivity reaction in monkey skin.. Cell Immunol 1993; 152: 614-22.
    CrossrefPubMedGoogle Scholar
  • 18 Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thicyanate-phenol-chloroform extraction.. Anal Biochem 1987; 162: 156-9.
    PubMedGoogle Scholar
  • 19 Scarpati EM, Wen D, Broze Jr. GJ, Miletich JP, Fladermeyer RR, Siegel NR, Sadler JE. Human tissue factor : cDNA sequence and chromosome localization of the gene.. Biochemistry 1987; 26: 5234-8.
    CrossrefPubMedGoogle Scholar
  • 20 Matsumoto K, Yamamoto J, Miura T. Lack of prognostic value of immuno-reactivity for p62 oncoprotein in colorectal carcinoma.. Int J Colorect Dis 1993; 8: 103-5.
    CrossrefPubMedGoogle Scholar
  • 21 Suzuki H, Matsumoto K, Koide A, Tada T, Fujino I, Okuda A, Shigemori C. Correlation of p53 with the clinicopathologic features and prognosis of colorectal adenocarcinoma.. Surgery Today 1994; 24: 85-7.
    CrossrefPubMedGoogle Scholar
  • 22 Mohri Y. Prognostic significance of E-Cadherin expression in human colorectal cancer tissue.. Surgery Today 1997; 27: 606-12.
    CrossrefPubMedGoogle Scholar
  • 23 Grimstad IA, Prydz H. Thromboplastin release, but not content, correlates with spontaneous metastasis of cancer cell.. Int J Cancer 1988; 41: 427-31.
    CrossrefPubMedGoogle Scholar
  • 24 Masuda M, Nakamura S, Murakami T, Koniyama Y, Takahashi H. Association of tissue factor with a gamma chain homodimer of the Ig E receptor type I in cultured human monocytes.. Eur J Immunol 1996; 26: 2529-32.
    CrossrefPubMedGoogle Scholar
  • 25 Folkman J. Tumor angiogenesis: therapeutic implications.. N Engl J Med 1971; 285: 1182-6.
    CrossrefPubMedGoogle Scholar
  • 26 Takahashi H, Satoh N, Wada K, Takakuwa E, Seki Y, Shibata A. Tissue factor in plasma of patients with disseminated intravascular coagulation.. Am J Haematol 1994; 46: 333-7.
    CrossrefPubMedGoogle Scholar
  • 27 Wada H, Nakase T, Nakaya R, Minamikawa K, Wakita Y, Kaneko T, Ohiwa M, Deguchi K, and Shirakawa S. Elevated plasma tissue factor antigen level in patients with disseminated intravascular coagulation.. Am J Haematol 1994; 45: 232-6.
    CrossrefPubMedGoogle Scholar
  • 28 Szczepanski M, Bardadine K, Zawadzki J, Pypno W. Procoagulant activity of gastric, colorectal, and renal cancer is factor VII-dependent. J Cancer Res.. Clin Oncol 1998; 114: 519-22.
    PubMedGoogle Scholar
  • 29 Naito S, Inoue S, Kinjo M, Tanaka K. Thromboplastic and fibrinolytic activities of culture human gastric cancer cell lines.. Gann 1983; 74: 241-7.
    PubMedGoogle Scholar
  • 30 Hu T, Bach RR, Horton R, Konigsberg WH, Todd MB. Procoagulant activity in cancer cells is dependent on tissue factor expression.. Oncol Res 1994; 6: 321-7.
    PubMedGoogle Scholar
  • 31 Asakura H, Kamikubo Y, Goto A, Shiratori Y, Yamazaki M, Jokaji H, Saito M, Uotani C, Kumabashiri I, Morishita E. et al. Role of tissue factor in disseminated intravascular coagulation.. Thromb Res 1995; 80: 217-24.
    CrossrefPubMedGoogle Scholar
  • 32 Silberberg JM, Gordon S, Zucker S. Identification of tissue factor in two human pancreatic cancer cell lines.. Cancer Res 1989; 49: 5443-7.
    PubMedGoogle Scholar
  • 33 Rao LV. Tissue factor as a tumor procoagulant.. Cancer Metastasis Rev 1992; 11: 249-66.
    CrossrefPubMedGoogle Scholar
  • 34 Lorenzet R, Peri G, Locati D, Allavena P, Colucci M, Semeraro N, Mantovani A, and Donati MB. Generation of procoagulant activity by mononuclear phagocytes: a possible mechanism contributing to blood clotting activation within malignant tissues.. Blood 1983; 62: 271-3.
    PubMedGoogle Scholar
  • 35 Geczy CL, Jones A. Procoagulant induction by human lymphokine and interferon gamma/PMA on a myelomonocytic cell line, RC2a.. Br J Haematol 1988; 70: 211-8.
    CrossrefPubMedGoogle Scholar
  • 36 Gregory SA, Kornbluth RS, Helin H, Remold HG, Edgington TS. Monocyte procoagulant inducing factor: a lymphokine involved in the T cell-instructed monocytes procoagulant response to antigen.. J Immunol 1986; 137: 3231-9.
    PubMedGoogle Scholar
  • 37 Moore KL, Andreoli SP, Esmon NL, Esmon CT, Bang NU. Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro.. J Clin Invest 79 124-30.
    PubMedGoogle Scholar
  • 38 Bevilacqua MP, Pober JS, Majeau GR, Cotran RS, Gimbrone Jr. MA. Inter-leukin-1 (IL-1) induces biosythesis and cell surface expression of procoagulant activity in human vascular endothelial cells.. J Exp Med 1984; 160: 618-23.
    CrossrefPubMedGoogle Scholar
  • 39 Zhang Y, Deng Y, Wendt T, Liliensiek B, Bierhaus A, Greten J, He W, Chen B, Hach-Wunderle V, Waldeherr R, Ziegler R, Mannel D, Stern DM, Nawroth PP. Intravenous somatic gene transfer with antisense tissue factor restores blood flow by reducing tumor necrosis factor-induced tissue factor expression and fibrin deposition in mouse meth-A sarcoma.. J Clin Invest 1996; 97: 2213-24.
    CrossrefPubMedGoogle Scholar
  • 40 Shoji M, Hancock WW, Abe K, Micko C, Casper KA, Baine RM, Wilcox JN, Danave I, Dillehay DL, Matthews E, Contrino J, Morrisey JH, Gordon S, Edgington TS, Kudryk B, Kreutzer DL, Rickles FR. Activation of coagulation and angiogenesis in cancer. Immunohistochemical localization in situ of clotting proteins and vascular endothelial growth factor in human cancer.. Amer J Pathol 1998; 152: 399-411.
    PubMedGoogle Scholar