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Methods Inf Med 2007; 46(02): 247-250
DOI: 10.1055/s-0038-1625416
Original Article
Schattauer GmbH

Neural Responses to Human Voice and Hemisphere Dominance for Lexical-semantic Processing

An fMRI Study
M. Koeda
1   Department of Bioinformatics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
6   Department of Neuropsychiatry, Nippon Medical School, Tokyo, Japan
,
H. Takahashi
2   National Institute of Radiological Sciences Brain Imaging Project, Chiba, Japan
,
N. Yahata
3   Department of Pharmacology, Nippon Medical School, Tokyo, Japan
,
M. Matsuura
4   Department of Biofunctional Informatics, Tokyo Medical and Dental University, Tokyo, Japan
,
K. Asai
5   Asai Hospital, Togane, Japan
,
Y. Okubo
6   Department of Neuropsychiatry, Nippon Medical School, Tokyo, Japan
,
H. Tanaka
1   Department of Bioinformatics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
7   Department of Bioinformatics and Computational Biology, School of Biomedical Sciences, Tokyo, Japan
› Author Affiliations
Further Information

Publication History

Publication Date:
11 January 2018 (online)

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Summary

Objectives : In our previous functional magnetic resonance imaging (fMRI) study, we determined that there was distinct left hemispheric dominance for lexical- semantic processing without the influence of human voice perception in right-handed healthy subjects. However, the degree of right-handedness in the right-handed subjects ranged from 52 to 100 according to the Edinburgh Handedness Inventory (EHI) score. In the present study, we aimed to clarify the correlation between the degree of right-handedness and language dominance in the fronto-temporo-parietal cortices by examining cerebral activation for lexical-semantic processing.

Methods : Twenty-seven normal right-handed healthy subjects were scanned by fMRI while listening to sentences (SEN), reverse sentences (rSEN), and identifiable non-vocal sounds (SND). Fronto-temporo-parietal activation was observed in the left hemisphere under the SEN - rSEN contrast, which included lexical- semantic processing without the influence of human voice perception. Laterality Indexwas calculated as LI = (L - R)/(L + R) X 100, L: left, R: right.

Results : Laterality Index in the fronto-temporo-parietal cortices did not correlate with the degree of right-handedness in EHI score.

Conclusions : The present study indicated that the degree of right-handedness from 52 to 100 in EHI score had no effect on the degree of left hemispheric dominance for lexical-semantic processing in right-handed healthy subjects.

Keywords

Lexical-semantic processing - cerebral laterality - fMRI - Laterality Index - handedness
 

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