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Thromb Haemost 1987; 58(03): 801-805
DOI: 10.1055/s-0038-1645993
Review Article
Schattauer GmbH Stuttgart

Baboon Models of Acute Arterial Thrombosis

Stephen R Hanson
The Roon Research Center for Arteriosclerosis and Thrombosis, Department of Basic and Clinical Research, Scripps Clinic and Research Foundation, La Jolla, California, USA
,
Laurence A Harker
The Roon Research Center for Arteriosclerosis and Thrombosis, Department of Basic and Clinical Research, Scripps Clinic and Research Foundation, La Jolla, California, USA
› Author Affiliations
Further Information

Publication History

Received 26 March 1987

Accepted after revision 25 June 1987

Publication Date:
28 June 2018 (online)

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Summary

In conclusion, we believe that the baboon offers many advantages as an experimental animal to study vascular disease, thrombus formation and dissolution, the effects of mediating variables, and the relative efficacy of therapeutic interventions. Each specific application for testing therapeutic agents may require testing in different model systems. For example, the AV vascular graft model is efficient, cost effective and well adapted to study interventions for acute arterialthrombosis. As the antithrombotic products of genetic engineering and molecular biology emerge, it will be increasingly important to have relevant, reproducible, and quantitative approaches to evaluate their effects in vivo.

Keywords

Arterial thrombosis - Thrombogenesis - Antiplatelet therapy - Thrombolytic therapy - Primate models
 

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