Download PDF
Thromb Haemost 1972; 27(01): 059-062
DOI: 10.1055/s-0038-1649009
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

Sedimentation Behavior of Fibrinogen from Normal and Bleeder Swine

R. G Cooper
1   Departments of Agricultural Chemistry and Physiology of The University of Missouri, Columbia, Missouri, 65201
,
C. N Cornell
1   Departments of Agricultural Chemistry and Physiology of The University of Missouri, Columbia, Missouri, 65201
,
M. E Muhrer
1   Departments of Agricultural Chemistry and Physiology of The University of Missouri, Columbia, Missouri, 65201
,
K Leimer
1   Departments of Agricultural Chemistry and Physiology of The University of Missouri, Columbia, Missouri, 65201
› Author AffiliationsThis investigation was supported by grant HE 07181 from the U. S. P. H. S. Exp. Sta. Paper =£7120.
Further Information

Publication History

Publication Date:
29 June 2018 (online)

    Permissions and Reprints

Summary

The Missouri Bleeder Swine have prolonged bleeding time, low factor VIII levels, reduced platelet adhesion, and respond to plasma and serum transfusions in a manner similar to that of patients with von Willebrand’s disease. The swine disease is thus more similar to von Willebrand’s disease than to classical hemophilia. The present work demonstrates that the sedimentation behavior of fibrinogen from these bleeder swine is like that of normal swine and does not show the anomalous sedimentation pattern of fibrinogen from classical hemophiliacs.

 

  • References

  • 1 Blombäck B, Blombäck M, Lauren T. C, Perrso H. Anomalous behavior of hemophilia A fibrinogen during ultracentrifugation. Biochim. biophys. Acta (Amst.) 97: 171-173. 1965;
    CrossrefPubMedGoogle Scholar
  • 2 Mertz E. T. The anomalie of a normal Duke’s and a very prolonged saline bleeding time in swine suffering from an inherited bleeding disease. Amer. J. Physiol 136: 360-363. 1942;
    PubMedGoogle Scholar
  • 3 Boqart R, Muhrer M. E. Inheritance of a hemophilia like condition in swine. J. Heredity 33: 59-64. 1942;
    CrossrefPubMedGoogle Scholar
  • 4 Cornell G. N, Muhrer M. E. Coagulation factors in normal and hemophiliac-type swine. Amer. J. Physiol 206: 926-928. 1964;
    PubMedGoogle Scholar
  • 5 Cooper R. G, Cornell G. N, Muhrer M. E, Garb S. Platelet adhesion in bleeder swine measured by glass bead column. Tex. Rep. Biol. Med 27: 955-961. 1969;
    PubMedGoogle Scholar
  • 6 Cornell C. N, Cooper R. G, Kahn R. A, Garb S. Platelet adhesiveness in normal and bleeder swine as measured in a celite system. Amer. J. Physiol 216: 1170-1175. 1969;
    PubMedGoogle Scholar
  • 7 Kahn R. A, Cooper R. G, Cornell C. N, Muhrer M. E. Electron microscopy of bleeder swine platelets. Amer. J. Yet. Res 31: 679-684. 1970;
    PubMedGoogle Scholar
  • 8 Muhrer M. E, Lechler E, Cornell C. N, Kirkland J. L. Antihemophilic factor levels in bleeder swine following infusions of plasma and serum. Amer. J. Physiol 208: 508-510. 1965;
    PubMedGoogle Scholar
  • 9 Biggs R, Matthews J. M. The treatment of hemorrhage in von Willebrand’s disease and the blood level of factor VIII (AHG). Brit. J. Hemat 09: 203-214. 1963;
    CrossrefPubMedGoogle Scholar
  • 10 Zimmerman T. S, Ratnoff O. D, Powell A. E. Immunological differentiation of classic hemophilia (factor VIII deficiency) and von Willebrand’s disease with some observations on combined deficiencies of antihemophilic factor and proaccelerin (factor V) and on an acquired circulating anticoagulant against antihemophilic factor. J. clin. Invest 50: 244-254. 1971;
    CrossrefPubMedGoogle Scholar
  • 11 Blombäck B, Blombäch M. Purification of human and bovine fibrinogen. Arkiv Kemi 12: 415-443. 1958;
    PubMedGoogle Scholar
  • 12 Ware A. G, Guest M. M, Seegers W. H. Fibrinogen: with special reference to its preparation and certain properties of the product. Arch. Biochem 13: 231-236. 1947;
    PubMedGoogle Scholar
  • 13 Spaet T. H, Kinsell B. G. Properties of bovine antihemophilic factor. Proc. Soc. exp. Biol. (N.Y.) 84: 314-317. 1953;
    CrossrefPubMedGoogle Scholar
  • 14 Brinkhous K. M, Morrison Jr. F. G, Muhrer M. E. Comparative study of clotting defects in human, canine, and porcine hemophilia. Fed. Proc 11: 409 1952;
    PubMedGoogle Scholar