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Thromb Haemost 1977; 37(02): 283-290
DOI: 10.1055/s-0038-1649229
Original Article
Schattauer GmbH

Kinetic Parameters of Platelet Aggregation as an Expression of Platelet Responsiveness

Ennio C Rossi
1   Hematology Section, Department of Medicine, Northwestern University School of Medicine, Chicago, Illinois, USA
,
Gerlinde Louis
1   Hematology Section, Department of Medicine, Northwestern University School of Medicine, Chicago, Illinois, USA
› Author Affiliations
Further Information

Publication History

Received 30 September 1976

Accepted 20 December 1976

Publication Date:
03 July 2018 (online)

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Summary

The kinetics of platelet aggregation induced by collagen and by ADP were studied. The maximum aggregation (ΔLTmax) and the ADP and collagen concentrations required to produce half-maximum aggregation (Kd) were determined using platelets obtained from normal individuals, individuals who ingested aspirin and individuals whose platelet-rich plasma (PRP) demonstrated spontaneous aggregation. The Kd and ΔLTmaxfor ADP-induced platelet aggregation were variable and markedly affected by the citrate concentration. Conversely, kinetic parameters of collagen-induced aggregation were more reproducible and less affected by citrate. The Kd for collagen in platelet aggregation was increased following aspirin ingestion and decreased in samples of PRP that demonstrated spontaneous aggregation. These results suggest that kinetic parameters of platelet aggregation may be useful to express the responsiveness of platelets.

 

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