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Thromb Haemost 1977; 37(03): 429-435
DOI: 10.1055/s-0038-1649251
Original Article
Schattauer GmbH

ADPase Activity of Normal and Atherosclerotic Human Aorta intima

A. du P Heyns
1   Department of Haematology and Internal Medicine, Faculty of Medicine, University of the Orange Free State, Bloemfontein, South Africa
,
C. J Badenhorst
1   Department of Haematology and Internal Medicine, Faculty of Medicine, University of the Orange Free State, Bloemfontein, South Africa
,
F. P Retief
1   Department of Haematology and Internal Medicine, Faculty of Medicine, University of the Orange Free State, Bloemfontein, South Africa
› Author Affiliations
Further Information

Publication History

Received 15 December 1976

Accepted 05 March 1977

Publication Date:
03 July 2018 (online)

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Summary

ADP plays a key role in platelet aggregation and the enzymatic removal of this nucleotide may be important in the pathogenesis of intravascular thrombosis and atherosclerosis. Aortic intima extracts have ADPase activity and is able to remove small quantities of ADP efficiently. ADPase activity was assayed by measuring the catabolism of 2 μM 14C-ADP (final concentration) by the tissue extracts. Extracts prepared from normal, moderately and severely atherosclerotic human aorta intimas showed a significant progressive decrease in ADPase activity with increasing atherosclerosis. ADPase activity of the arch, thoracic and abdominal regions of normal aortas did not vary significantly, and thus did not correlate with the anatomical distribution of atherosclerosis. Vascular ADPase activity seems relevant in thrombogenesis since it may be a link between blood platelets and blood vessel wall interaction.

 

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