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Thromb Haemost 1971; 25(01): 098-104
DOI: 10.1055/s-0038-1654283
Originalarbeiten – Original Articles – Travaux Originaux
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Aspirin Inhibition of In Vivo Effects of Intestinal Alkaline Phosphatase on Platelets[*]

P. G Iatridis
1   Departments of Physiology, Schools of Medicine, University of North Carolina, Chapel Hill, N. C., U.S.A., and University of Athens, Greece
,
S. G Iatridis
1   Departments of Physiology, Schools of Medicine, University of North Carolina, Chapel Hill, N. C., U.S.A., and University of Athens, Greece
,
J. H Ferguson
1   Departments of Physiology, Schools of Medicine, University of North Carolina, Chapel Hill, N. C., U.S.A., and University of Athens, Greece
› Author Affiliations
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Publication History

Publication Date:
28 June 2018 (online)

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Summary

Intravenous injections of 10 mg/kg purified intestinal alkaline phosphatase (AlPh) into (I) normal (non-aspirinized) rabbits and (II) aspirinized rabbits, show that aspirin inhibits significantly the AlPh effects on platelet aggregation and adhesion. Since aspirin does not change the assayable injected AlPh activity or its electrophoretic distribution, and whereas aspirin inhibits the platelet ADP release, it is very possible that the effects of AlPh on platelets are due to platelet ADP release by AlPh.

Aspirin also inhibits the hypercoagulable effect of the injected AlPh. If aspirin acetylates the platelet membrane by its acetyl group, this could compete with HF (Hageman factor) which is a sialoglycoprotein, and could thus prevent the activation of HF on the surface of platelets.

* Aided by a Faculty Research Grant VB051 and by a grant from the “National Hellenique Research Foundation”


 

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