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Thromb Haemost 1961; 6(02): 371-380
DOI: 10.1055/s-0038-1654568
Originalarbeiten — Original Articles — Travaux Originaux
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On the Physiological Antiacogulating System[*]

B. A Kudrjashov
1   Moscow State University, Laboratory of the Physiology and Biochemistry of Blood Coagulation
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Publication History

Publication Date:
12 July 2018 (online)

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Summary

1. The influence of intravenous injections of thrombin has been tested on frogs and rats.

2. After thrombin or thromboplastin injection the animals produce anticoagulant activity which is, to a certain extent, quantitatively related to the activity injected.

3. If the animals tested are under anaesthesia or if the medulla oblongata is switched off the humoral reflex reaction is blockaded.

4. The importance of these observations for the prophylaxis of early postoperative thromboses is discussed.

5. These results combined with the effect of thrombin injection on the clotting factors in vivo are used for the elaboration of a coagulation scheme.

* The present article develops a concept of coagulation which does not fit into the generally accepted scheme. However according to our principles ideas of different schools may be published in our journal even if the editorial board holds a different view point.


 

  • References

  • (1) Kudriashov B. A, Ulytina P. D. Nature 182: 397 1958;
    PubMed
  • (2) Kudriashov B. A, Ulytina P. D. Doch Acad. Nauk USSR 120: 677 1958;
    PubMed
  • (3) Kudriashov B. A. Nature 184: 454 1959;
    CrossrefPubMed
  • (4) Kudriashov B. A. Voproci Med. Chemii 6: 3 1960;
    PubMed
  • (5) Kudriashov B. A, Kalishevsky T. M. Dock Acad. Nauk USSR 131: 213 1960;
    PubMed
  • (6) Niewiarowski S, Kowalski E, Stachurska J. Acta biochim. pol. 6: 43 1959;
    PubMed
  • (7) Macfarlane R. J. Physiol. 106: 104 1947;
    CrossrefPubMed
  • (8) Fulton L. D, Page E. W. Proc. Soc. exp. Biol. (N. Y.) 68: 596 1948;
    CrossrefPubMed
  • (9) Künitz M. J. gen. Physiol. 29: 149 1945;
    PubMed
  • (10) Kudriashov B. A, Pastorova V. E. Dock Akad. Nauk USSR 130: 1382 1960;
    PubMed
  • (11) Wilgram G. F. Proc. Soc. exp. Biol. (N. J.) 99: 496 1958;
    CrossrefPubMed
  • (12) Wilgram G. F. J. exp. Med. 109: 293 1959;
    CrossrefPubMed
  • (13) Thomas W. A, Hrtroft W. S. Circulation 19: 65 1959;
    CrossrefPubMed
  • (14) Gormsen J. Brit. J. Haemat. 5: 257 1959;
    CrossrefPubMed
  • (15) Hume R. Brit. Heart J. 20: 15 1958;
    CrossrefPubMed
  • (16) Dorosh L. A. Izv. Akad. Nauk Usbek. S.S.R., Ser. Fiziol. Med. 1: 49 1959;
    PubMed
  • (17) Stefanini M, Dameshek W. The Hemorrhagic Disorders. New York: 1955
    Google Scholar
  • (18) Seegers W. H, Johnson S. A. Amer. J. Physiol. 184: 259 1956;
    PubMed
  • (19) Seegers W. H, Johnson S. A, Penner J. A. Canad. J. Biochem. 36: 887 1956;
    PubMed