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Thromb Haemost 1964; 12(02): 452-461
DOI: 10.1055/s-0038-1655558
Originalarbeiten – Original Articles – Travaux Originaux
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Studies on the Pathogenesis of the Generalized Shwartzman Reaction

I. Alterations in the Coagulation System During the Generalized Shwartzman Reaction of the Pregnant Rabbit
F Rodríguez-Erdmann   *
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Publication Date:
27 June 2018 (online)

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Summary

The generalized Shwartzman reaction (gSr) was produced in pregnant rabbits by means of a single intravenous injection of E.-coli endotoxin. The animals developed a profound and a haemorrhagic diathesis. The haemorrhagic condition is thought to be the result of an acute consumption of the plasma-factors of the coagulation system. The pathogenesis of the gSr is discussed in the light of literature dealing with this phenomenon.

* Present address: Dept. of Haematology. Tufts-New England Medical Center, Boston, 11, Mass. 02111, USA.


 

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