J Knee Surg 2022; 35(03): 249-254
DOI: 10.1055/s-0041-1740931
Special Focus Section

Are All Unloader Braces Created Equal? Recommendations for Evidence-Based Implementation of Unloader Braces for Patients with Unicompartmental Knee OA

1   Department of Orthopedic Surgery, Missouri Orthopedic Institute, University of Missouri, Columbia, Missouri
,
Jonathan Williams
2   Thompson Laboratory for Regenerative Orthopedics, University of Missouri System, Columbia, Missouri
,
Cory R. Crecelius
1   Department of Orthopedic Surgery, Missouri Orthopedic Institute, University of Missouri, Columbia, Missouri
,
Lindsey Redington
1   Department of Orthopedic Surgery, Missouri Orthopedic Institute, University of Missouri, Columbia, Missouri
,
Trent M. Guess
3   Department of Physical Therapy and Orthopedic Surgery, University of Missouri, Columbia, Missouri
,
James L. Cook
1   Department of Orthopedic Surgery, Missouri Orthopedic Institute, University of Missouri, Columbia, Missouri
› Institutsangaben

Abstract

Unicompartmental knee osteoarthritis (UKOA) is a complex issue that is estimated to affect roughly 28% of patients with knee OA, and can result in severe cartilage degeneration, meniscus deficiency, and concomitant varus or valgus malalignment. This malalignment results in abnormally high joint reaction forces in the affected compartment, which can elicit pain, cause dysfunction, and exacerbate joint degradation. For more than two decades, the use of knee unloader braces has been advocated as a cost-effective option for symptomatic management of UKOA.

During bipedal ambulation with a normal lower extremity mechanical axis, ground reaction forces create a knee adduction moment (KAM) such that the medial compartment of the knee experiences approximately 60% of joint loading and the lateral compartment experiences approximately 40% of joint loading. UKOA disrupts the mechanical axis, altering KAM and joint loading and causing pain, dysfunction, and disease progression. In theory, knee unloader braces were designed to mitigate the symptoms of UKOA by normalizing KAM via shifts in the lever arms about the knee. However, studies vary, and suggest that push-mechanism knee unloaders do not consistently provide significant biomechanical benefits for medial or lateral UKOA. Current evidence suggests that pull-mechanism unloaders may be more effective, though contrasting data have also been reported, such that further validation is necessary. The purpose of our study was to synthesize current best evidence for use of knee unloader braces for management of UKOA to suggest evidence-based best practices as well as gaps in knowledge to target for future studies. Unloader bracing for patients with UKOA appears to be a cost-effective treatment option for patients with medial UKOA who have insurance coverage. Pull-mechanism unloader bracing should be considered in conjunction with other nonoperative management therapies for those who are willing to adhere to consistent brace use for weight-bearing activities.



Publikationsverlauf

Eingereicht: 02. August 2021

Angenommen: 16. November 2021

Artikel online veröffentlicht:
24. Dezember 2021

© 2021. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 
  • References

  • 1 Heekin RD, Fokin AA. Incidence of bicompartmental osteoarthritis in patients undergoing total and unicompartmental knee arthroplasty: is the time ripe for a less radical treatment?. J Knee Surg 2014; 27 (01) 77-81
  • 2 Sharma L, Song J, Dunlop D. et al. Varus and valgus alignment and incident and progressive knee osteoarthritis. Ann Rheum Dis 2010; 69 (11) 1940-1945
  • 3 Sharma L, Song J, Felson DT, Cahue S, Shamiyeh E, Dunlop DD. The role of knee alignment in disease progression and functional decline in knee osteoarthritis. JAMA 2001; 286 (02) 188-195
  • 4 Hewett TE, Noyes FR, Barber-Westin SD, Heckmann TP. Decrease in knee joint pain and increase in function in patients with medial compartment arthrosis: a prospective analysis of valgus bracing. Orthopedics 1998; 21 (02) 131-138
  • 5 Pollo FE, Otis JC, Backus SI, Warren RF, Wickiewicz TL. Reduction of medial compartment loads with valgus bracing of the osteoarthritic knee. Am J Sports Med 2002; 30 (03) 414-421
  • 6 Self BP, Greenwald RM, Pflaster DS. A biomechanical analysis of a medial unloading brace for osteoarthritis in the knee. Arthritis Care Res 2000; 13 (04) 191-197
  • 7 Lindenfeld TN, Hewett TE, Andriacchi TP. Joint loading with valgus bracing in patients with varus gonarthrosis. Clin Orthop Relat Res 1997; (344) 290-297
  • 8 Kirkley A, Webster-Bogaert S, Litchfield R. et al. The effect of bracing on varus gonarthrosis. J Bone Joint Surg Am 1999; 81 (04) 539-548
  • 9 Divine JG, Hewett TE. Valgus bracing for degenerative knee osteoarthritis: relieving pain, improving gait, and increasing activity. Phys Sportsmed 2005; 33 (02) 40-46
  • 10 Birmingham TB, Kramer JF, Kirkley A, Inglis JT, Spaulding SJ, Vandervoort AA. Knee bracing for medial compartment osteoarthritis: effects on proprioception and postural control. Rheumatology (Oxford) 2001; 40 (03) 285-289
  • 11 Brouwer RW, van Raaij TM, Verhaar JA, Coene LN, Bierma-Zeinstra SM. Brace treatment for osteoarthritis of the knee: a prospective randomized multi-centre trial. Osteoarthritis Cartilage 2006; 14 (08) 777-783
  • 12 Hart HF, Collins NJ, Ackland DC, Cowan SM, Hunt MA, Crossley KM. Immediate effects of a brace on gait biomechanics for predominant lateral knee osteoarthritis and valgus malalignment after anterior cruciate ligament reconstruction. Am J Sports Med 2016; 44 (04) 865-873
  • 13 Prodromos CC, Andriacchi TP, Galante JO. A relationship between gait and clinical changes following high tibial osteotomy. J Bone Joint Surg Am 1985; 67 (08) 1188-1194
  • 14 Kutzner I, Trepczynski A, Heller MO, Bergmann G. Knee adduction moment and medial contact force – facts about their correlation during gait. PLoS ONE 2013;8(12):e81036
  • 15 Nadaud MC, Komistek RD, Mahfouz MR, Dennis DA, Anderle MR. In vivo three-dimensional determination of the effectiveness of the osteoarthritic knee brace: a multiple brace analysis. J Bone Joint Surg 2005; 87 (Suppl. 02) 114-119
  • 16 Dessery Y, Belzile ÉL, Turmel S, Corbeil P. Comparison of three knee braces in the treatment of medial knee osteoarthritis. Knee 2014; 21 (06) 1107-1114
  • 17 Ebert JR, Hambly K, Joss B, Ackland TR, Donnelly CJ. Does an unloader brace reduce knee loading in normally aligned knees?. Clin Orthop Relat Res 2014; 472 (03) 915-922
  • 18 Lee H, Ha D, Kang Y-S, Park H-S. Biomechanical analysis of the effects of bilateral hinged knee bracing. Front Bioeng Biotechnol 2016; 4: 50
  • 19 Matsuno H, Kadowaki KM, Tsuji H. Generation II knee bracing for severe medial compartment osteoarthritis of the knee. Arch Phys Med Rehabil 1997; 78 (07) 745-749
  • 20 Haladik JA, Vasileff WK, Peltz CD, Lock TR, Bey MJ. Bracing improves clinical outcomes but does not affect the medial knee joint space in osteoarthritic patients during gait. Knee Surg Sports Traumatol Arthrosc 2014; 22 (11) 2715-2720
  • 21 Nagai K, Yang S, Fu FH, Anderst W. Unloader knee brace increases medial compartment joint space during gait in knee osteoarthritis patients. Knee Surg Sports Traumatol Arthrosc 2019; 27 (07) 2354-2360
  • 22 Mohd Sharif NA, Usman J, Wan Safwani WKZ. et al. Effects of simple knee sleeves on pain and knee adduction moment in early unilateral knee osteoarthritis. Proc Inst Mech Eng H 2019; 233 (11) 1132-1140
  • 23 Heiden TL, Lloyd DG, Ackland TR. Knee joint kinematics, kinetics and muscle co-contraction in knee osteoarthritis patient gait. Clin Biomech (Bristol, Avon) 2009; 24 (10) 833-841
  • 24 Messier SP. Osteoarthritis of the knee and associated factors of age and obesity: effects on gait. Med Sci Sports Exerc 1994; 26 (12) 1446-1452
  • 25 Childs JD, Sparto PJ, Fitzgerald GK, Bizzini M, Irrgang JJ. Alterations in lower extremity movement and muscle activation patterns in individuals with knee osteoarthritis. Clin Biomech (Bristol, Avon) 2004; 19 (01) 44-49
  • 26 Kapadia BH, Cherian JJ, Starr R. et al. Gait using pneumatic brace for end-stage knee osteoarthritis. J Knee Surg 2016; 29 (03) 218-223
  • 27 Barrett DS, Cobb AG, Bentley G. Joint proprioception in normal, osteoarthritic and replaced knees. J Bone Joint Surg Br 1991; 73 (01) 53-56
  • 28 Marks R. Further evidence of impaired position sense in knee osteoarthritis. Physiother Res Int 1996; 1 (02) 127-136
  • 29 Fantini Pagani CH, Willwacher S, Kleis B, Brüggemann G-P. Influence of a valgus knee brace on muscle activation and co-contraction in patients with medial knee osteoarthritis. J Electromyogr Kinesiol 2013; 23 (02) 490-500
  • 30 Ostrander RV, Leddon CE, Hackel JG, O'Grady CP, Roth CA. Efficacy of unloader bracing in reducing symptoms of knee osteoarthritis. Am J Orthop 2016; 45 (05) 306-311
  • 31 Dennis DA, Komistek RD, Nadaud MC, Mahfouz M. Evaluation of off-loading braces for treatment of unicompartmental knee arthrosis. J Arthroplasty 2006; 21 (4, Suppl 1): 2-8
  • 32 Hjartarson HF, Toksvig-Larsen S. The clinical effect of an unloader brace on patients with osteoarthritis of the knee, a randomized placebo controlled trial with one year follow up. BMC Musculoskelet Disord 2018; 19 (01) 341
  • 33 Horlick S, Loomer R. Valgus knee bracing for medial gonarthrosis. Clin J Sport Med 1993; 3 (04) 251-255
  • 34 Wilson B, Rankin H, Barnes CL. Long-term results of an unloader brace in patients with unicompartmental knee osteoarthritis. Orthopedics 2011; 34 (08) e334-e337
  • 35 Messier SP, Mihalko SL, Legault C. et al. Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial. JAMA 2013; 310 (12) 1263-1273
  • 36 Lee PY, Winfield TG, Harris SR, Storey E, Chandratreya A. Unloading knee brace is a cost-effective method to bridge and delay surgery in unicompartmental knee arthritis. BMJ Open Sport Exerc Med 2017; 2 (01) e000195
  • 37 Minzlaff P, Saier T, Brucker PU, Haller B, Imhoff AB, Hinterwimmer S. Valgus bracing in symptomatic varus malalignment for testing the expectable “unloading effect” following valgus high tibial osteotomy. Knee Surg Sports Traumatol Arthrosc 2015; 23 (07) 1964-1970
  • 38 Ramsey DK, Russell ME. Unloader braces for medial compartment knee osteoarthritis: implications on mediating progression. Sports Health 2009; 1 (05) 416-426