Horm Metab Res 2002; 34(1): 27-31
DOI: 10.1055/s-2002-19963
Original Clinical

© Georg Thieme Verlag Stuttgart · New York

Effect of Short-Term Low-Intensity Exercise on Insulin Sensitivity, Insulin Secretion, and Glucose and Lipid Metabolism in Non-Obese Japanese Type 2 Diabetic Patients

H.  Kishimoto 1 , A.  Taniguchi 1 , M.  Fukushima 2 , M.  Sakai 1 , K.  Tokuyama 3 , T.  Oguma 1 , K.  Nin 4 , I.  Nagata 1 , R.  Hayashi 1 , M.  Kawano 1 , K.  Hayashi 1 , Y.  Tsukamoto 1 , T.  Okumura 1 , S.  Nagasaka 5 , H.  Mizutani 1 , Y.  Nakai 6
  • 1Division of Diabetes, Kansai-Denryoku Hospital, Osaka, Japan
  • 2Department of Metabolism and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  • 3Laboratory of Biochemistry of Exercise and Nutrition, Institute of Health and Sports Science, Tsukuba University, Ibaraki, Japan
  • 4Nagoya University School of Health Sciences, Aichi, Japan
  • 5Division of Endocrinology and Metabolism, Jichi Medical School, Tochigi, Japan
  • 6College of Medical Technology, Kyoto University, Kyoto, Japan.
Further Information

Publication History

15 February 2001

20 August 2001

Publication Date:
14 August 2002 (online)

Abstract

The aim of the present study was to investigate the effects of short-term physical exercise that did not change body mass on insulin sensitivity, insulin secretion, and glucose and lipid metabolism in 39 non-obese Japanese type 2 diabetic patients. Insulin sensitivity and insulin secretion were estimated with homeostasis model assessment insulin resistance (HOMA-IR) and HOMA-B-cell function proposed by Matthews et al., respectively. All patients were hospitalized and were engaged in low-intensity exercise that consisted of walking and dumbbell exercise for successive 7 days. There were no changes in hospital diet and the dose of any medications used throughout the study. Fasting glucose, insulin, and lipids were measured before and after exercise.

After exercise, serum triglyceride levels significantly decreased, but no significant changes were observed in total and HDL cholesterol concentrations. Fasting glucose, insulin, and HOMA-IR levels significantly decreased after exercise, but HOMA-B-cell function did not change during the study. There was no significant difference between BMI levels before and after exercise.

From these results, it can be concluded that short-term (7 days) low-intensity physical exercise combined with hospital diet reduces serum triglycerides, insulin resistance, and fasting glucose levels without affecting BMI in non-obese Japanese type 2 diabetic patients.

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A. Taniguchi, M.D.

First Department of Internal Medicine · Kansai-Denryoku Hospital

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