Int J Sports Med 2003; 24(2): 114-117
DOI: 10.1055/s-2003-38202
Physiology & Biochemistry
© Georg Thieme Verlag Stuttgart · New York

Magnitude- and Time-Dependence of the Effect of Treadmill Exercise on Cell Proliferation in the Dentate Gyrus of Rats

Y.-P.  Kim1 , H.-B.  Kim1 , M.-H.  Jang1 , B.-V.  Lim1 , Y.-J.  Kim1 , H.  Kim2 , S.-S.  Kim2 , E.-H.  Kim3 , C.-J.  Kim1
  • 1Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea
  • 2Research Institute of Sports Science, Korea University, Seoul, Korea
  • 3Department of Meridianology, College of Oriental Medicine, Semyung University, Jechon, Korea
Further Information

Publication History



Accepted after revision: July 30, 2002

Publication Date:
01 April 2003 (online)

Abstract

The effect of treadmill exercise on cell proliferation in the dentate gyrus was studied in Sprague-Dawley rats via 5-bromo-2'-deoxyuridine (BrdU)-specific immunohistochemistry. For studying the dependence of this effect on the magnitude of exercise, animals were divided into the control, light-exercise, moderate-exercise, and severe-exercise groups; different exercise regimens were applied to the groups. To study the temporal dependence of this effect, animals were divided into the control, 1-day-exercise, 3-days-exercise, 7-days-exercise, 14-days-exercise, and 28-days-exercise groups; the regimen used on the light-exercise group was applied to each of the exercise group over the respective number of days. Cell proliferation was most prominent in the light-exercise group (p < 0.001) and reached a maximum level after 7 days of exercise (p < 0.001). In this study, it was shown that cell proliferation is modulated by the intensity and duration of treadmill exercise.

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C.-J. Kim

Department of Physiology · College of Medicine · Kyung Hee University

# 1 Hoigi-dong · Dongdaemoon-gu · Seoul 130-701 · South Korea ·

Phone: +82-2-961-0407

Fax: +82-2-964-2195

Email: changju@khu.ac.kr