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Horm Metab Res 1992; 24(2): 56-59
DOI: 10.1055/s-2007-1003255
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© Georg Thieme Verlag, Stuttgart · New York

Dilatory and Inotropic Effects of Corticotropin-Releasing Factor (CRF) on the Isolated Heart

Effects on Atrial Natriuretic Peptide (ANP) ReleaseM. Grunt, C. Haug, L. Duntas, P. Pauschinger1 , V. Maier, E. F. Pfeiffer
  • Abteilung Angewandte Physiologie und Innere Medizin I, Medizinische Klinik und Poliklinik, Universität Ulm, Ulm, Germany
  • 1Abteilung Angewandte Physiologie, Universität Ulm, Ulm, Germany
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Publication History

1990

1991

Publication Date:
14 March 2008 (online)

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Summary

The effects of CRF administration on cardiac performance, coronary flow and ANP release were investigated in the rat heart. Isolated hearts were perfused at a constant filling pressure according to working heart model with a Krebs-Henseleit solution containing glucose and insulin, saturated with a gas mixture containing 95% O2 and 5% CO2. Administration of CRF via a cannula into the left atrium elicited a prolonged increase in the coronary flow rate and a transient increase in the aortic pressure resulting in an overall increase in the pressure-volume work. The oxygen consumption, after the administration of CRF, increased in accordance with the cardiac effort. No changes were observed in the spontaneous heart rate. Furthermore, administration of CRF induced a short-term increase of ANP release into the coronary perfusate.

Our experiments suggest that administration of CRF produces a prolonged dilatory effect on the coronary arteries while producing a transient positive inotropic effect and a transient increase of ANP release on the isolated rat heart.

Key words

Hemodynamics - Isolated Perfused Rat Heart - Working Heart Model - Corticotropin-Releasing Factor - Atrial Natriuretic Factor

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