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Semin Liver Dis 1999; 19(1): 15-26
DOI: 10.1055/s-2007-1007094
ORIGINAL ARTICLE

© 1999 by Thieme Medical Publishers, Inc.

Mechanisms of Cell Engraftment During Liver Repopulation with Hepatocyte Transplantation

Sanjeev Gupta1 , Kuldeep K. Bhargava2 , Phyllis M. Novikoff3
  • 1Marion Bessin Liver Research Center, Cancer Research Center, General Clinical Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York
  • 2Nuclear Medicine at Long Island Jewish Medical Center Campus, Albert Einstein College of Medicine, Bronx, New York
  • 3Marion Bessin Liver Research Center, Department of Pathology, Albert Einstein College of Medicine, Bronx, New York
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Publication History

Publication Date:
17 March 2008 (online)

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ABSTRACT

Hepatocyte transplantation has excited much interest among investigators for applications in cell therapy and studies of fundamental mechanisms concerning liver biology. Progress in these areas has been greatly facilitated by the development of novel animal models. An understanding of early events during engraftment of transplanted cells is essential for optimal repopulation of the liver. Insights into how transplanted cells integrate in the parenchyma of the liver with reconstitution of specific plasma membrane structures is critical in devising therapeutic strategies for specific disorders. Moreover, these insights are necessary for understanding mechanisms concerning regulation of cell proliferation and gene expression in transplanted hepatocytes. Finally, analysis of the safety of cell transplantation is necessary for clinical applications of liver repopulation with cell transplantation. This review highlights selected advances in related areas concerning liver repopulation.

KEY WORDS

hepatocyte - transplantation - liver

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