Growth Hormone Stimulates the Peripheral Conversion of Thyroxine into Triiodothyronine by Increasing the Liver 5'-Monodeiodinase Activity in the Fasted and Normal Fed Chicken

Summary

Normal fed and 2 days fasted Warren chickens were injected intravenously with 100 μg of ovine growth hormone (GH) and ovine prolactin and plasma concentrations of thyroid hormones were assayed prior and up to 2 h after injection. Fasting alone decreases T₃, but increases T₄. An injection of GH resulted in increases of plasma T₃ concentrations in two fasting experiments by 40% (after 3/4 h) and 104% (after 1 h). In normal fed animals no increase is observed in the first experiment, whereas a 35% increase occurs in the second one. An injection of 100 μg prolactin does not influence T₃ in normal fed or fasting animals. Both GH and prolactin, however, may decrease plasma concentrations of T₄. In a separate experiment 50 μg and 200 μg of GH raised the decreased T₃ levels after fasting by 39% and 60% respectively 1 h after injection and by 24 and 61% respectively in normal fed chicken, whereas prolactin was ineffective in this regard. Using Hisex chickens, the influence of an injection of 100 μg GH on plasma concentrations of thyroid hormones could be confirmed. At the same time GH increases the liver 5'-monodeiodinase activity by 330% after 1 h and by 147% after 2 h.

The peroxidase activity is not influenced in normal fed chickens, but GH decreases this activity in food deprived animals after 1 h and 2 h. It is concluded that ovine GH, but not prolactin, stimulates the peripheral conversion of T₄ into T₃ in both normal fed and food deprived chicken and that this effect is dose dependent.

Key-Words

GH and Peripheral T₄ to T₃ Conversion