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Horm Metab Res 1987; 19(7): 335-338
DOI: 10.1055/s-2007-1011815
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Calcium Absorption in Corticoid Treated Subjects Effects of a Single Oral Dose of Calcitriol

C. Colette1 , L. Monnier1 , N. Pares Herbute1 , F. Blotman2 , J. Mirouze1
  • 1Clinique des Maladies Métaboliques et Endocriniennes, Montpellier, France
  • 2Réadaptation Fonctionelle, Hôpital Lapeyronie, Montpellier, France
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Publication History

1986

1986

Publication Date:
14 March 2008 (online)

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Summary

We compared the fractional absorption of calcium (FACa, 6 h, % TD) and the radiocalcium transit (% TD per min) in seven glucocorticoid-treated patients (10-25 mg prednisolone per day) and in seven normal subjects, in the basal state and 12 h after an oral dose of synthetic 1,25-(OH)2D (3 μg). In the basal state, the radiocalcium transit was significantly decreased (P < 0.02) at 15 min in patients treated with prednisolone, but FACa at 6 h was not significantly decreased (51±5 vs. 60±5% TD). 12 h after an oral dose of 1,25-(OH)2D which resulted in supraphysiologic plasma levels, FACa increased significantly (P < 0.02) in both groups but the peak absorption rate of Ca remained lower in the corticoid-treated patients than in controls (P < 0.02). The results suggest that glucocorticoids decrease the 1,25-(OH)2D-dependent transport of calcium across the proximal small intestine.

Key-Words

Fractional Absorption of Calcium - Corticoids - 1,25-(OH)2D

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