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Horm Metab Res 1986; 18(10): 706-709
DOI: 10.1055/s-2007-1012412
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Immunoreactive Somatomedin B (RIA-B) in the Circulation of Healthy Adults and Patients with Endocrine Disorders

Anne Tham1 , V. R. Sara1 , M. Bäckström2 , K. Hall2 , G. Kallner3 , J. G. Ljunggren4 , L. Wetterberg1
  • 1Department of Psychiatry, St. Göran's Hospital, Stockholm, Sweden
  • 2Department of Endocrinology, Karolinska Hospital, Stockholm, Sweden
  • 3Department of Medicine, Södersjukhuset, Stockholm, Sweden
  • 4Department of Medicine St. Göran's Hospital, Stockholm, Sweden
Further Information

Publication History

1985

1985

Publication Date:
14 March 2008 (online)

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Summary

The serum and cerebrospinal fluid (CSF) levels of immunoreactive somatomedin B (RIA-B) were examined throughout life in healthy adult humans. A significant decline in serum RIA-B was observed in subjects over 60 years of age. No significant diurnal, daily, or monthly serum variation was observed in healthy subjects aged 20-60 years. However, women taking oral contraceptives had elevated RIA-B values. No significant decline in CSF RIA-B was observed in subjects over 60 years of age. A significantly lower level of RIA-B in CSF was observed in subjects sampled at 20.00 h compared to subjects sampled in the morning. A significant decline in serum RIA-B was observed in patients with hypopituitarism and diabetes mellitus and a significant elevation of serum RIA-B levels was observed in patients with hyperthyroidism. CSF RIA-B was significantly elevated in patients with Cushing's syndrome.

Key-Words

Somatomedin B - Human Serum Spreading Factor - Pituitary Disorders - Hyperthyroidism - Hypothyroidism - Diabetes Mellitus - Cushing's Syndrome

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