Neues aus der Cochrane Library: Probiotika für die Prävention der kindlichen Antibiotika-assoziierten Diarrhö

Zusammenfassung

Basierend auf einer 2006 publizierten Metaanalyse [1] ist von denselben Autoren in der aktuellen Ausgabe der Cochrane Library (April 2007) nun ein Review zur Frage der Prävention der AAD bei Kindern durch Probiotika erschienen [2]. In der Per-Protokoll-Analyse fand sich ein relatives Risiko (RR) für die Häufigkeit einer AAD von 0,49 (0,32; 0,74); in der Intention-to-Treat-Analyse konnte allerdings keine signifikante Wirkung nachgewiesen werden. Insgesamt sind die Ergebnisse vielversprechend, weitere Studien zur definitiven Klärung der Wirksamkeit von Probiotika zur Prävention der AAD sind jedoch notwendig.

Abstract

Based on a meta-analysis published in 2006 on the prevention of paediatric antibiotic-associated diarrhoea with probiotics a Cochrane review by the same authors has been released within the current edition of the Cochrane Library (Issue 2, 2007). The per protocol analysis showed a relative risk for the incidence of AAD of 0.49 (0.32; 0.74). These findings could not be confirmed by the intention to treat analysis. These data are promising, but future studies will be necessary to clarify the role of probiotics for the prevention of AAD.

Schlüsselwörter

Cochrane Library - Metaanalyse - systematische Übersichtsarbeit - Probiotika - Kindliche Antibiotikaassoziierte Diarrhö

Key words

Cochrane Library - meta-analysis - systematic review - probiotics - paediatric antibioticassociated diarrhoea

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