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Int J Sports Med 2007; 28(12): 1065-1069
DOI: 10.1055/s-2007-965130
Genetics & Molecular Biology

© Georg Thieme Verlag KG Stuttgart · New York

Physical Activity, Cdx-2 Genotype, and BMD

P. Gentil1 , R. M. Lima1 , T. C. L. Lins2 , B. S. Abreu2 , R. W. Pereira1 , 2 , R. J. Oliveira1
  • 1Programa de Pós Graduação em Educação Física, Universidade Católica de Brasília, Taguatinga, Brazil
  • 2Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Taguatinga, Brazil
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Publication History

accepted after revision December 24, 2006

Publication Date:
05 July 2007 (online)

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Abstract

The present study investigated the interaction between Cdx-2 polymorphism and physical activity level over bone mineral density (BMD) variation in Brazilian postmenopausal women. One hundred and ninety women volunteered to participate in the study (66.6 ± 5.3 years, 64.58 ± 11.74 kg and 151.94 ± 6.36 cm). Physical activity level (PAL) was assessed using the international physical activity questionnaire (IPAQ). Lumbar spine (L2 - L4), femoral neck, great trochanter and Wards' triangle bone mineral density (BMD) were measured by dual-energy X‐ray absorptiometry (DXA). The Cdx-2 polymorphism was genotyped by minisequencing, using the SNaPshot™ Multiplex System (Applied Biosystems, Foster City, CA, USA). Overall, no significant association was found between Cdx-2 polymorphism and adjusted BMD at any site. However, the results revealed a significant interaction between PAL and Cdx-2 genotype on adjusted femoral neck and Wards' triangle BMD. Active women carrying the Cdx-G/G genotype showed higher adjusted femoral neck and Wards' triangle BMD than inactive women carrying the same genotype, thus suggesting a larger chronic response to physical activity. These results suggest that, in postmenopausal women, the Cdx-2 polymorphism does not influence BMD by itself; however, it seems to affect the BMD response to physical activity since only the Cdx-G/G genotype carriers presented significant differences between active and inactive.

Key words

vitamin D receptor - osteoporosis - genetics - minisequencing

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 Mr.
Paulo Gentil

Programa de Pós Graduação em Educação Física
Universidade Católica de Brasília

QS 07 lote 01 EPCT

71.966 - 700 Taguatinga

Brazil

Phone: + 55 61 33 56 93 56

Fax: + 55 61 33 56 93 56

Email: paulogentil@hotmail.com

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