Int J Sports Med 2008; 29(8): 679-687
DOI: 10.1055/s-2007-965808
Clinical Sciences

© Georg Thieme Verlag KG Stuttgart · New York

Side Effects of Anabolic Androgenic Steroids Abuse

A. Bonetti1 , F. Tirelli1 , A. Catapano2 , D. Dazzi3 , A. Dei Cas3 , F. Solito1 , G. Ceda3 , C. Reverberi4 , C. Monica5 , S. Pipitone5 , G. Elia6 , M. Spattini1 , G. Magnati3
  • 1Department of Clinical Science, Curriculum of Sports Science and Physical Exercise, University of Parma, Parma, Italy
  • 2Department of Phamacologic Sciences, University of Milan, Milano, Italy
  • 3Department of Internal Medicine and Biomedical Sciences, University of Parma, Parma, Italy
  • 4Department of Heart and Cardiac Surgery, Azienda Ospedaliero-Universitaria Parma, Parma, Italy
  • 5Central Laboratory, Azienda Ospedaliero-Universitaria Parma, Parma, Italy
  • 6Infective Diseases Section, Azienda Ospedaliero-Universitaria Parma, Parma, Italy
Further Information

Publication History

accepted after revision September 3, 2007

Publication Date:
14 November 2007 (online)

Abstract

Long-term side effects of high doses of anabolic androgenic steroids self-administration were evaluated in this study. Twenty male bodybuilders, voluntarily starting steroid self-administration, were followed every 6 months over 2 years. Physical examination, haematological, metabolic and endocrine variables, semen analysis, hepatic and prostate ultrasound and echocardiographic evaluations were performed. LH values (baseline 3.43 ± 1.75) were suppressed at 18 (1.98 ± 1.99) (p = 0.026) and 24 (2.43 ± 2.17) (p = 0.026), and FSH (3.95 ± 2.01) at 6 (3.01 ± 2.16) (p = 0.031), 12 (2.45 ± 2.54) (p = 0.029), 18 (2.02 ± 2.29) (p = 0.032) and 24 (3.42 ± 2.64) (p = 0.032) months and SHBG (34.11 ± 10.88) values significantly lowered at 12 (24.81 ± 12.49) (p < 0.05), 18 (21.28 ± 11.15) (p < 0.01), 24 months (25.42 ± 11.16) (p < 0.01). A significant decrease in spermatozoa count (p < 0.01), and fertility index (p = 0.01) occurred. HDL-cholesterol (baseline 56.94 ± 13.54) was reduced at 18 (41.86 ± 14.17) (p < 0.01) and 24 (43.82 ± 18.67) (p < 0.05) months and Apo A-1 at 12 (p < 0.001), 18 (p = 0.05) and 24 (p = 0.05) months. The most important long-term adverse effects were lower fertility and the impairment of lipid profile associated with an increased cardiovascular risk.

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Prof. Antonio Bonetti

Department of Clinical Science, Curriculum of Sports Science and Physical Exercise
University of Parma

Via Gramsci

43100 Parma

Italy

Fax: + 39 05 21 98 54 68

Email: antonio.bonetti@unipr.it