Molekular-basierte Therapiekonzepte beim fortgeschrittenen Pankreaskarzinom

Zusammenfassung

Seit der Zulassung des Nukleosidanalogons Gemcitabin gilt dieses Zytostatikum als eine Standardtherapie für Patienten mit fortgeschrittenem Pankreaskarzinom. Nachdem mehrere Studien zur einer Gemcitabin-basierten Kombinationschemotherapie keinen relevanten Überlebensvorteil gegenüber der Gemcitabin-Monotherapie zeigen konnten, rücken in letzter Zeit auch beim Pankreaskarzinom molekulare Therapieansätze - basierend auf neuen Erkenntnissen der Tumorbiologie - zunehmend ins wissenschaftliche und auch klinische Interesse. Die vorliegende Übersichtsarbeit gibt einen kurzen Überblick zu diese aktuellen Studienergebnisse und zudem einen Ausblick über neue molekular-basierte Therapiekonzepte beim fortgeschrittenen Pankreaskarzinom.

Summary

Since the approval of the nucleoside analogue gemcitabine, this cytotoxic drug is regarded as a standard of care for patients with advanced pancreatic cancer. After several clinical trials evaluating gemcitabine-based combination chemotherapy have failed to demonstrate a significant survival benefit compared to single-agent gemcitabine, molecular-targeted treatment regimens for pancreatic cancer - based on new knowledge in tumor biology - are an increasing focus of scientific as well as clinical interest. This review gives a short overview of recent data from clinical trials and summarizes future perspectives of new molecular-based treatment strategies for advanced pancreatic cancer.

Schlüsselwörter

Pankreaskarzinom - Chemotherapie - Gemcitabin

Key words

pancreatic carcinoma - chemotherapy - gemcitabine

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