Dtsch Med Wochenschr 2007; 132(36): 1837-1841
DOI: 10.1055/s-2007-984975
Übersicht | Review article
Nephrologie, Hämatologie
© Georg Thieme Verlag KG Stuttgart · New York

Therapie der renalen Anämie - mit welchem Ziel?

What are the aims and targets of renal anemia therapy?K.-U Eckardt1
  • 1Medizinische Klinik 4, Schwerpunkt Nephrologie und Hypertensiologie, Universitätsklinikum Erlangen und Klinikum Nürnberg
Further Information

Publication History

eingereicht: 16.4.2007

akzeptiert: 5.7.2007

Publication Date:
28 August 2007 (online)

Literatur

  • 1 Astor B C, Mutner P, Levin A, Eustace J A, Coresh J. Association of kidney function with anemia: the Third National Health and Nutrition Examination Survey (1988 - 1994).  Arch Intern Med. 2002;  162 1401-1408
  • 2 Besarab A, Bolton W K, Browne J K. et al . The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and Epoetin.  N Engl J Med. 1998;  339 584-590
  • 3 Drueke T B, Locatelli F, Clyne N. et al . Normalization of hemoglobin level in patients with chronic kidney disease and anemia.  N Engl J Med. 2006;  355 2071-2084
  • 4 Eckardt K U. Cardiovascular consequences of renal anaemia and erythropoietin therapy.  Nephrol Dial Transplant. 1999;  14 1317-1323
  • 5 Eschbach J, Egrie J C, Downing M R, Browne J K, Adamson J W. Correction of the anemia of end-stage renal disease with recombinant human erythropoietin.   N Engl J Med. 1987;  316 73-78
  • 6 Ezekowitz J A. et al . Anemia is common in heart failure and is associated with poor outcomes: insights from a cohort of 12 065 patients with new-onset heart failure.  Circulation. 2003;  107 223-225
  • 7 Hahn E A, Cella D, Chassany O, Fairclough D L, Wong G Y, Hays R DA. Comparison of the Precision of Health-Related Quality of Life Data Relative to Other Clinical Measures.  Mayo ClinProc. 2007;  in press
  • 8 Hörl W. Clinical aspects of iron use in the anemia of kidney disease.  J Am Soc Nephrol. 2007;  18 382-393
  • 9 Macdougall I, Eckardt K U. Novel strategies for stimulating erythropoiesis and potential new treatments for anemia.  Lancet. 2006;  368 947-953
  • 10 Mix T C, Brenner R M, Cooper M E. et al . Rationale - Trial to Reduce Cardiovascular Events with Aranesp Therapy (TREAT): evolving the management of cardiovascular risk in patients with chronic kidney disease.  Am Heart J. 2005;  149 408-413
  • 11 Mohanram A, Zhang Z, Shahinfar S, Keane W F, Brenner B M, Toto R D. Anemia and end-stage renal disease in patients with type 2 diabetes and nephropathy.  Kidney Int. 2004;  66 1131-1138
  • 12 Nangaku M, Eckardt K U. Pathogenesis of renal anemia.  Semin Nephrol. 2006;  26 261-268
  • 13 National Kidney Foundation . KDOQI Clinical practice guidelines and clinical practice recommendations for anemia in chronic kidney disease: 2007 update of hemoglobin targets.  Am J Kidney Dis. 2007;  in preparation
  • 14 Ofsthun N, Labrecque J, Lacson E. et al . The effects of higher hemoglobin levels on mortality and hospitalization in hemodialysis patients.  Kidney Int. 2003;  63 1908-1914
  • 15 Parfrey P S, Foley R N, Wittreich B H. et al . Double-blind comparison of full and partial anemia correction in incident hemodialysis patients without symptomatic heart disease.  J Am Soc Nephrol. 2005;  16 2180-2189
  • 16 Sarnak M J, Tighiouart H, Manjunath G, MacLeod B, Griffith J, Salem D, Levey A S. Anemia as a risk factor for cardiovascular disease in The Atherosclerosis Risk in Communities (ARIC) study.  J Am Coll Cardiol. 2002;  40 27-33
  • 17 Singh A K, Szczech L, Tang K L. et al . Correction of anemia with epoetin alfa in chronic kidney disease.  N Engl J Med. 2006;  355 2085-2098
  • 18 Volkova N, Arab L. Evidence-based systematic literature review of hemoglobin/hematocrit and all-cause mortality in dialysis patients.  Am J Kidney Dis. 2006;  47 24-36

Prof. Dr. K.-U. Eckardt

Medizinische Klinik 4

Krankenhausstraße 12

91054 Erlangen

Phone: 09131/8539002

Fax: 09131/8539209

Email: med4@rzmail.uni-erlangen.de

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