Exp Clin Endocrinol Diabetes 2008; 116(1): 53-57
DOI: 10.1055/s-2007-990276
Article

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Static Lung Volumes in Patients with Cushing's Disease

A. D. Azezli 1 , T. Bayraktaroglu 1 , T. Ece 2 , F. Kutluturk 1 , Y. Orhan 1
  • 1Department of Internal Medicine, Division of Endocrinology and Metabolism, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
  • 2Department of Pulmonary Disease, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
Further Information

Publication History

received 06.06.2007 first decision 13.07.2007

accepted 23.08.2007

Publication Date:
31 October 2007 (online)

Abstract

Objective: Numerous clinical manifestations have been described in association with Cushing's syndrome. There are no eligible data on pulmonary function tests in Cushing's disease (CD). We aimed to asses pulmonary function tests including spirometry in a series of patients with active CD.

Materials and Methods: This cross-sectional study comprised 10 patients with Cushing's disease (F/M, 9/1). The forced expiratory volume in 1st second (FEV1), the forced vital capacity (FVC), the FEV1/FVC ratio and the forced expiratory flow over the middle half of the FVC (FEF 25-75%) values and predicted values were determined by spirometry.

Results: Mean age, height, weight, body mass index were 36.7±12.6 yrs (range 22-63 years), 156.9±8.4 cm, 74.1±10.7 kg, 29.6±3.8 kg/m2, respectively. Spirometric abnormalities (impairment of FEV1, FVC, FEV1/FVC and FEF 25-75 values) were not detected, and there were no significant differences compared to reference values. Disease duration and cortisol concentrations by HDDSTs were negatively correlated with predicted FEV1/FVC values and the percentage of predicted FEV1 ratios, respectively.

Discussion: The lung volume and ventilatory performance by spirometry were not disturbed in patients with endogenous hypercostisolism due to Cushing's disease.

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Correspondence

T. BayraktarogluMD 

Department of Internal Medicine

Division of Endocrinology and Metabolism

Istanbul University, Istanbul Faculty of Medicine

34390 Fatih

Istanbul

Turkey

Phone: +90/212/414 20 00/328 93GSM: +90/505/676 63 01

Fax: +90/212/635 88 76

Email: baytaner@yahoo.com