Dtsch Med Wochenschr 2007; 132(45): 2378-2382
DOI: 10.1055/s-2007-993084
Aktuelle Diagnostik & Therapie | Review article
Gastroenterologie, Heptatologie, Gynäkologie
© Georg Thieme Verlag KG Stuttgart · New York

Intrahepatische Schwangerschaftscholestase: neue molekulare Mechanismen und klinische Behandlungspfade

Intrahepatic cholestasis of pregnancy: new molecular mechanisms and clinical pathwaysF. Lammert1 , C. Reichel2
  • 1Medizinische Klinik und Poliklinik I, Universitätsklinikum Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn;
  • 2Reha-Zentrum Bad Brückenau, Klinik Hartwald, Bad Brückenau
Further Information

Publication History

eingereicht: 12.6.2007

akzeptiert: 9.8.2007

Publication Date:
31 October 2007 (online)

Literatur

  • 1 Bacq Y, Sapey T, Brechot M C, Pierre F. et al . Intrahepatic cholestasis of pregnancy: a French prospective study.  Hepatology. 1997;  26 358-364
  • 2 Bacq Y. Intrahepatic cholestasis of pregnancy.  Clin Liver Dis. 1999;  3 1-13
  • 3 Beuers U. Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasis.  Nat Clin Pract Gastroenterol Hepatol. 2006;  3 318-328
  • 4 Binder T, Salaj P, Zima T. et al . Randomized prospective comparative study of ursodeoxycholic acid and S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis of pregnancy.  J Perinat Med. 2006;  34 383-391
  • 5 Brites D. Intrahepatic cholestasis of pregnancy: changes in maternal-fetal bile acid balance and improvement by ursodeoxycholic acid.  Ann Hepatol. 2002;  1 20-28
  • 6 Burrows R F, Clavisi O, Burrows E. Interventions for treating cholestasis in pregnancy.  Cochrane Database Syst Rev. 2001;  CD000493
  • 7 Diac M, Kenyon A, Nelson-Piercy C. et al . Dexamethasone in the treatment of obstetric cholestasis: a case series.  J Obstet Gynaecol. 2006;  26 110-114
  • 8 Dixon P H, Weerasekera N, Linton K J. et al . Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking.  Hum Mol Genet. 2000;  9 1209-1217
  • 9 Girling J C. Obstetric cholestasis.  Royal College of Obstetricians and Gynaecologists Guidelines. 2006;  43 1-10
  • 10 Glantz A, Marschall H U, Lammert F, Mattsson L A. Intrahepatic cholestasis of pregnancy: a randomized controlled trial comparing dexamethasone and ursodeoxycholic acid.  Hepatology. 2005;  42 1399-1405
  • 11 Glantz A, Marschall H U, Mattsson L A. Intrahepatic cholestasis of pregnancy: relationships between bile acid levels and fetal complication rates.  Hepatology. 2004;  40 467-474
  • 12 Hirvioja M L, Tuimala R, Vuori J. The treatment of intrahepatic cholestasis of pregnancy by dexamethasone.  Br J Obstet Gynaecol. 1992;  99 109-111
  • 13 Jacquemin E, Cresteil D, Manouvrier S. et al . Heterozygous non-sense mutation of the MDR3 gene in familial intrahepatic cholestasis of pregnancy.  Lancet. 1999;  353 210-211
  • 14 Keitel V, Vogt C, Häussinger D, Kubitz R. Combined mutations of canalicular transporter proteins cause severe intrahepatic cholestasis of pregnancy.  Gastroenterology. 2006;  131 624-629
  • 15 Kenyon A P, Piercy C N, Girling J. et al . Pruritus may precede abnormal liver function tests in pregnant women with obstetric cholestasis: a longitudinal analysis.  Br J Obstet Gynaecol. 2001;  108 1190-1192
  • 16 Kondrackiene J, Beuers U, Kupcinskas L. Efficacy and safety of ursodeoxycholic acid versus cholestyramine in intrahepatic cholestasis of pregnancy.  Gastroenterology. 2005;  129 894-901
  • 17 Lammert F, Marschall H U, Glantz A, Matern S. Intrahepatic cholestasis of pregnancy: molecular pathogenesis, diagnosis and management.  J Hepatol. 2000;  33 1012-1021
  • 18 Lammert F, Marschall H U, Matern S. Intrahepatic cholestasis of pregnancy.  Curr Treat Options Gastroenterol. 2003;  6 123-132
  • 19 Lammert F, Rath W. Lebererkrankungen. München, Jena: Urban & Fischer In: Kainer F, Hrsg. Facharzt Geburtsmedizin 2006: 523-554
  • 20 Muehlenberg K, Wiedmann K H, Keppeler H. et al . Rezidivierende Schwangerschaftscholestase und perlenschnurartige Choledocholithiasis bei einer Patientin mit Stoppcodon im ABCB4-Gen des hepatischen Phospholipid-Transporters.  Z Gastroenterol. 2007;  im Druck
  • 21 Mullenbach R, Bennett A, Tetlow N. et al . ATP8B1 mutations in British cases with intrahepatic cholestasis of pregnancy.  Gut. 2005;  54 829-834
  • 22 Painter J N, Savander M, Ropponen A. et al . Sequence variation in the ATP8B1 gene and intrahepatic cholestasis of pregnancy.  Eur J Hum Genet. 2005;  13 435-439
  • 23 Palma J, Reyes H, Ribalta J. et al . Ursodeoxycholic acid in the treatment of cholestasis of pregnancy: a randomized, double-blind study controlled with placebo.  J Hepatol. 1997;  27 1022-1028
  • 24 Paus T C, Schneider G, van de Vondel P. et al . Diagnosis and therapy of intrahepatic cholestasis of pregnancy.  Z Gastroenterol. 2004;  42 623-628
  • 25 Reyes H, Baez M E, Gonzalez M C. et al . Selenium, zinc and copper plasma levels in intrahepatic cholestasis of pregnancy, in normal pregnancies and in healthy individuals, in Chile.  J Hepatol. 2000;  32 542-549
  • 26 Reyes H, Sjövall J. Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy.  Ann Med. 2000;  32 94-106
  • 27 Ropponen A, Sund R, Riikonen S. et al . Intrahepatic cholestasis of pregnancy as an indicator of liver and biliary diseases: a population-based study.  Hepatology. 2006;  43 723-728
  • 28 Schneider G, Paus T C, Kullak-Ublick G A. et al . Linkage between a new splicing site mutation in the MDR3 alias ABCB4 gene and intrahepatic cholestasis of pregnancy.  Hepatology. 2007;  45 150-158
  • 29 Wasmuth H E, Glantz A, Keppeler H. et al . Intrahepatic cholestasis of pregnancy: the severe form is associated with common variants of the hepatobiliary phospholipid transporter ABCB4 gene.  Gut. 2007;  56 265-270
  • 30 Williamson C, Gorelik J, Eaton B M. et al . The bile acid taurocholate impairs rat cardiomyocyte function: a proposed mechanism for intra-uterine fetal death in obstetric cholestasis.  Clin Sci. 2001;  100 363-369
  • 31 Williamson C, Hems L M, Goulis D G. et al . Clinical outcome in a series of cases of obstetric cholestasis identified via a patient support group.  Br J Obstet Gynaecol. 2004;  111 676-681

Prof. Dr. med. Frank Lammert

Medizinische Klinik und Poliklinik I, Universitätsklinikum Bonn

Sigmund-Freud-Straße 25

53127 Bonn

Phone: 0228/287/11249

Fax: 0228/287/14698

Email: frank.lammert@ukb.uni-bonn.de

    >