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Neuropediatrics 1983; 14(3): 144-148
DOI: 10.1055/s-2008-1059567
© Georg Thieme Verlag KG Stuttgart · New York

Cranial Computed Tomography of 64 Children in Continuous Complete Remission of Leukemia I: Relations to Therapy Modalities

E.  Habermalz1 , H. J. Habermalz1 , U.  Stephani2 , G.  Henze2 , H.  Riehm2 , F.  Hanefeld2
  • 1Radiologische Klinik des Klinikums Charlottenburg, Freie Universität Berlin, Spandauer Damm 130, 1000 Berlin 19. Federal Republic of Germany
  • 2Kinderklinik des Klinikums Charlottenburg, Freie Universtität Berlin, Heubner Weg 6, 1000 Berlin 19, Federal Republic of Germany
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Publication History

Publication Date:
19 March 2008 (online)

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Cranial Computed Tomography of 64 Children in Continuous Complete Remission of Leukemia II: Relations to Patient Data and Neurological ComplicationsNeuropediatrics 1983; 14(03): 149-154
DOI: 10.1055/s-2008-1059568

Abstract

64 children with acute lymphoblastic leukemia and non Hodgkin's lymphoma in continuous complete remission were studied by cranial computed tomography two months to 7 years after cessation of antileukemic treatment. 17 (27%) patients showed abnormal widening (grade 2) of external cerebrospinal fluid spaces, 20 (31 %) minimal widening (grade 1). A significant correlation between grade 2 abnormalities and the duration of maintenance therapy and single cranial radiation dose was found, whereas the correlations with total radiation dose and with intensity of induction protocols were not significant. Widening of external cerebrospinal fluid spaces after cessation of therapy persisted.

Key words

Cranial computed tomography - Childhood leukemia - Radiation therapy - Chemotherapy

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