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Neuropediatrics 1982; 13(3): 155-157
DOI: 10.1055/s-2008-1059615
CASE REPORTS

© Georg Thieme Verlag KG Stuttgart · New York

Progressive Neurological Disorder Associated with Obstructive Jaundice and Vitamin E Deficiency

B. W. Lloyd , V.  Dubowitz
  • Department of Paediatrics and Neonatal Medicine, Institute of Child Health, Hammersmith Hospital, Du Cane Road, London W12 OHS
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Publication History

Publication Date:
05 May 2008 (online)

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Abstract

A ten-year-old girl had obstructive jaundice in the newborn period which persisted for 4 years despite choledochojejunostomy at 6 weeks. From the age of 6 years she developed a progressive neurological syndrome characterized mainly by dysarthria and ataxia. A causal relationship with her profound vitamin E deficiency seemed likely. Treatment with vitamin E over a 2 1/2; year period appeared to arrest the progression of the neurological deficit and subsequent increase in dosage produced some improvement in her ataxia.

Key words

Neonatal jaundice - Vitamin E deficiency - Progressive neurological syndrome - Ataxia - Dysarthria